E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients

Sreedhar Ganga, Shaik Mabu Shareef, Naser Ashraf Tadvi, Syeda Ayesha Siddiqua.

Abstract
Background: Diabetes mellitus type 2 is associated with deteriorating blood sugar levels along with countless metabolic disorders. Treatment strategy plays a crucial role in achieving target blood sugar levels to reduce morbidity and early mortality. Diabetes mellitus type 2 is a chronic, long-term medical condition, in which the body does not produce insulin or is unable to utilize it properly resulting in uncontrolled blood sugar levels. Oral antidiabetic drugs are given as mono and combination therapy to achieve controlled blood sugar levels, based on the clinical conditions of each patient.

Aims and Objective: The purpose of our study is to compare the efficacy and adverse effects in monotherapy with that of combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients.

Materials and Methods: A prospective cross-sectional study of 11 months period was conducted on 200 patients, in the Department of General Medicine of a Tertiary Care Hospital. Ethics committee permission was obtained from the institutional ethical committee before initiation of the study. Based on the oral anti-diabetic therapy pattern, patients were divided into three groups, Group 1 (Monotherapy), Group 2 (Dual therapy), and Group 3 (Triple therapy). Following inclusion and exclusion criteria, demographic parameters, and oral anti-diabetic therapy patterns were collected and assessed for efficacy and adverse effects.

Results: Among 200 patients studied, 50% received monotherapy (Group 1), 30% received dual therapy (Group 2), and 20% received triple therapy (Group 3) treatment. Fasting blood sugar, postprandial blood sugar, and glycosylated hemoglobin levels were monitored. Controlled blood glucose levels were achieved successfully in combination therapy groups and it was found to be more efficacious than monotherapy group. Patients on monotherapy had less adverse effects than combination therapy.

Conclusion: Combination therapy was substantial in controlling blood sugar levels compared to monotherapy. Combination therapy is a better treatment choice for diabetes mellitus type 2 patients. Adverse effects were reported fewer in the monotherapy group in comparison with combination therapy groups.

Key words: Monotherapy; Combination Therapy; Fasting Blood Sugar; Postprandial Blood Sugar; Glycosylated Hemoglobin; Adverse Effects


 
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How to Cite this Article
Pubmed Style

Ganga S, Shareef SM, Tadvi NA, Siddiqua SA. A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. Natl J Physiol Pharm Pharmacol. 2021; 11(6): 600-605. doi:10.5455/njppp.2021.11.01021202126012021


Web Style

Ganga S, Shareef SM, Tadvi NA, Siddiqua SA. A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. http://www.njppp.com/?mno=46129 [Access: June 01, 2021]. doi:10.5455/njppp.2021.11.01021202126012021


AMA (American Medical Association) Style

Ganga S, Shareef SM, Tadvi NA, Siddiqua SA. A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. Natl J Physiol Pharm Pharmacol. 2021; 11(6): 600-605. doi:10.5455/njppp.2021.11.01021202126012021



Vancouver/ICMJE Style

Ganga S, Shareef SM, Tadvi NA, Siddiqua SA. A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. Natl J Physiol Pharm Pharmacol. (2021), [cited June 01, 2021]; 11(6): 600-605. doi:10.5455/njppp.2021.11.01021202126012021



Harvard Style

Ganga, S., Shareef, . S. M., Tadvi, . N. A. & Siddiqua, . S. A. (2021) A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. Natl J Physiol Pharm Pharmacol, 11 (6), 600-605. doi:10.5455/njppp.2021.11.01021202126012021



Turabian Style

Ganga, Sreedhar, Shaik Mabu Shareef, Naser Ashraf Tadvi, and Syeda Ayesha Siddiqua. 2021. A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. National Journal of Physiology, Pharmacy and Pharmacology, 11 (6), 600-605. doi:10.5455/njppp.2021.11.01021202126012021



Chicago Style

Ganga, Sreedhar, Shaik Mabu Shareef, Naser Ashraf Tadvi, and Syeda Ayesha Siddiqua. "A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 600-605. doi:10.5455/njppp.2021.11.01021202126012021



MLA (The Modern Language Association) Style

Ganga, Sreedhar, Shaik Mabu Shareef, Naser Ashraf Tadvi, and Syeda Ayesha Siddiqua. "A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients." National Journal of Physiology, Pharmacy and Pharmacology 11.6 (2021), 600-605. Print. doi:10.5455/njppp.2021.11.01021202126012021



APA (American Psychological Association) Style

Ganga, S., Shareef, . S. M., Tadvi, . N. A. & Siddiqua, . S. A. (2021) A comparative study of efficacy and adverse effects of monotherapy with combination therapy for oral anti-diabetics in diabetes mellitus type 2 patients. National Journal of Physiology, Pharmacy and Pharmacology, 11 (6), 600-605. doi:10.5455/njppp.2021.11.01021202126012021