Abstract
Background: Microalbuminuria documents earliest evidence of diabetic nephropathy and is a major predictor of end stage renal disease. Uncontrolled hyperglycemia has been recognized to be associated with higher incidence of microvascular complications in Type II diabetes mellitus. Studies have shown that severity of nephropathy is correlated with microalbuminuria which depends on sustained mean hyperglycemic level over a prolonged period.

Aims & Objective: To find the role of glycemic control in the presence of microalbuminuria in Type II diabetics.

Materials and Methods: The study comprised of 60 Type II diabetes patients aged between 40-60 years attending Sri Devaraj Urs Medical College, Kolar. Divided into two groups each comprising of 30 individuals: Group I HbA1c < 7% - Controlled Diabetic group and Group II HbA1c > 7 % - Uncontrolled Diabetic Group. Compared with Control Group comprising of 30 age-matched healthy participants HbA1c<6%. Glycosylated Hemoglobin and Microalbuminuria were estimated in all the participants. The results were statistically analyzed by One-way ANOVA and chi-square test.

Results: Uncontrolled diabetics showed higher incidence of microalbuminuria (53.33%) with mean HbA1C 8.47 ± 0.84 compared to Controlled diabetics (23.33%) with mean HbA1C 6.81 ± 0.19. Microalbuminuria also showed a direct relationship with glycemic status of an individual.

Conclusion: Uncontrolled hyperglycemia is associated with higher incidence of micro vascular complications like nephropathy in diabetes. HbA1c is an indicator of long-term blood glucose concentrations. Microalbuminuria serves as a warning to achieve good glycemic control and prevent further worsening of diabetes related complications.