A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure

Parul  Sharma; Maloy B Mandal

doi:10.5455/njppp.2019.9.0414916052019

2025, Vol: 15, Issue: 6

15 / 6Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form

« Previous Article

Original Research
Online Published: 29 May 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(7): 661-667

doi: 10.5455/njppp.2019.9.0414916052019

A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure

Parul Sharma, Maloy B Mandal.

Cited By:4

Abstract
Background: Prevailing standard of living allows generous usage of plastic containers to store, transport, and serve edibles. A chemical named bisphenol A (BPA) leaches from plastic containers into the edibles. Ingestion of BPA contaminated food is known to alter intestinal motility in addition to detrimental effects on fetal development, fertility, behavior, cognitive functions, immunity, and metabolism. These BPA-induced ill effects on health led to marketing regulation on BPA and introduction of bisphenol S (BPS) as a safer substitute of BPA. However, BPS is yet to be evaluated for its effects on gut motility.

Aims and Objectives: Therefore, this study was aimed to assess comparative effects of BPS and BPA on gut motility.

Materials and Methods: In an organ bath preparation, isometric contractions were recorded from segments of dissected gastric and small intestinal muscle strips prepared from rat gut, and cumulative concentration response of BPS and BPA on in vitro gut contractility was evaluated.

Results: Both BPS and BPA treatment significantly diminished basal tone, maximum contractile tension, and the contractile frequency of spontaneous contractions in gastric as well as small intestinal muscle strips.

Conclusion: From the present observation, it was apparent that both BPA and BPS have similar toxicity on gastric as well as small intestinal motility. Thus, the use of BPS as a substitute of BPA needs to be more critically evaluated.

Key words: Bisphenol A; Bisphenol S; Gut Motility; Plastic Toxins; In vitro Gut Contractility; Gastric Contractility; Small Intestinal Contractility; Albino Rats

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Parul Sharma Articles by Maloy B Mandal
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Sharma P, Mandal MB. A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 661-667. doi:10.5455/njppp.2019.9.0414916052019

Web Style

Sharma P, Mandal MB. A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. https://www.njppp.com/?mno=43809 [Access: November 03, 2025]. doi:10.5455/njppp.2019.9.0414916052019

AMA (American Medical Association) Style

Sharma P, Mandal MB. A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol. 2019; 9(7): 661-667. doi:10.5455/njppp.2019.9.0414916052019

Vancouver/ICMJE Style

Sharma P, Mandal MB. A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol. (2019), [cited November 03, 2025]; 9(7): 661-667. doi:10.5455/njppp.2019.9.0414916052019

Harvard Style

Sharma, P. & Mandal, . M. B. (2019) A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. Natl J Physiol Pharm Pharmacol, 9 (7), 661-667. doi:10.5455/njppp.2019.9.0414916052019

Turabian Style

Sharma, Parul, and Maloy B Mandal. 2019. A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 661-667. doi:10.5455/njppp.2019.9.0414916052019

Chicago Style

Sharma, Parul, and Maloy B Mandal. "A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 661-667. doi:10.5455/njppp.2019.9.0414916052019

MLA (The Modern Language Association) Style

Sharma, Parul, and Maloy B Mandal. "A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure." National Journal of Physiology, Pharmacy and Pharmacology 9.7 (2019), 661-667. Print. doi:10.5455/njppp.2019.9.0414916052019

APA (American Psychological Association) Style

Sharma, P. & Mandal, . M. B. (2019) A comparison of effects of bisphenol A and bisphenol S on rat gut contractility in vitro after acute exposure. National Journal of Physiology, Pharmacy and Pharmacology, 9 (7), 661-667. doi:10.5455/njppp.2019.9.0414916052019

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article