Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

Naveen Pokala; Naveen Alasyam; Kavitha Rasamal

doi:10.5455/njppp.2019.9.0412713042019

2026, Vol: 16, Issue: 2

16 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form
Title Page

« Previous Article

Original Research
Online Published: 23 Apr 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561

doi: 10.5455/njppp.2019.9.0412713042019

Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

Naveen Pokala, Naveen Alasyam, Kavitha Rasamal.

Cited By:12

Abstract
Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants.

Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits.

Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 10001500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin.

Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo.

Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Key words: Andrographis paniculata; Antipyretic; Digital Thermometer; Prostaglandin E1; Vitex negundo

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Naveen Pokala Articles by Naveen Alasyam Articles by Kavitha Rasamal
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561.

doi:10.5455/njppp.2019.9.0412713042019

Web Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. https://www.njppp.com/?mno=41407 [Access: June 26, 2026].

doi:10.5455/njppp.2019.9.0412713042019

AMA (American Medical Association) Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 556-561.

doi:10.5455/njppp.2019.9.0412713042019

Vancouver/ICMJE Style

Pokala N, Alasyam N, Rasamal K. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol. (2019), [cited June 26, 2026]; 9(6): 556-561.

doi:10.5455/njppp.2019.9.0412713042019

Harvard Style

Pokala, N., Alasyam, . N. & Rasamal, . K. (2019) Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. Natl J Physiol Pharm Pharmacol, 9 (6), 556-561.

doi:10.5455/njppp.2019.9.0412713042019

Turabian Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. 2019. Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 556-561.

doi:10.5455/njppp.2019.9.0412713042019

Chicago Style

Pokala, Naveen, Naveen Alasyam, and Kavitha Rasamal. "Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 556-561.

doi:10.5455/njppp.2019.9.0412713042019

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2019.9.0412713042019

APA (American Psychological Association) Style

doi:10.5455/njppp.2019.9.0412713042019

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article