Abstract
Background: With increasing age, men experience a gradual decline in testosterone levels. It had long been considered that male sex is a strong risk factor for coronary artery disease (CAD).

Aim and Objective: The aim of the study was to evaluate the difference between the Plasma Sex Hormone and the degree of Coronary Artery Stenosis in male patients undergoing Coronary Angiography and in matched controls.

Materials and Methods: This study was done at the Department of Physiology, Thanjavur Medical College Tamil Nadu. Participants (n = 80) were recruited from the population in and around Thanjavur. The Institute Ethical Committee approval was obtained for this study. Subjects who met inclusion and exclusion criteria were included in this study as control group: Group A (n = 40) and study group: Group B (n = 40). Informed, written consent was taken from both groups. We studied the Plasma Sex Hormone parameters such as Serum Testosterone level (ng/dL), follicle-stimulating hormone level (mIU/ml), and luteinizing hormone level (mIU/ml) were analyzed by Chemo Luminescence Immunoassay. Before the hormonal assay, the angiogram report was obtained from the cardiologist.

Results: The mean testosterone level was 6.837 ± 2.330 for Group A and the mean testosterone level for Group B was 4.967 ± 2.734, for which P = 0.001 (<0.05) which is statistically significant.

Conclusion: It has been concluded that the association between the Plasma Sex Hormones and the degree of Coronary Artery Stenosis in male patients undergoing coronary angiography is statistically significant compared to the control group, which means a decrease in testosterone level increases the risk of occurrence of coronary vascular events.

Key words: Testosterone; Follicle-stimulating Hormone; Luteinizing Hormone; Coronary Artery Disease; Coronary Artery Stenosis