E-ISSN 2231-3206 | ISSN 2320-4672
 

Review Article 


A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management

Shailendra D, Sudheera Polavarapu, Rajeev Sai Moram.

Abstract
Pulmonary fibrosis as a complication of COVID-19 has been widely reported. Several studies have reported prolonged respiratory symptoms in significant numbers of people lasting months after the acute episode of COVID-19 infection. Nintedanib is being explored as a potential therapeutic agent in the treatment of post-COVID-19 pulmonary fibrosis. However, the exact role of nintedanib in the treatment of post-COVID-19 pulmonary fibrosis is not clear. Objectives of this article are to perform a scoping review of the literature on the mechanism of pulmonary fibrosis, role of nintedanib in the treatment of post-COVID-19 pulmonary fibrosis, and emerging treatments in the treatment of post-COVID-19 pulmonary fibrosis. The United States Clinical Trials Registry and Clinical Trials Registry of India were searched to identify studies evaluating the role of nintedanib in post-COVID-19 pulmonary fibrosis. Embase and PubMed databases were searched and relevant articles were reviewed. Over all 26 article in PubMed and 67 articles in Embase were reviewed. There are several ongoing studies evaluating the safety and efficacy of nintedanib in the treatment of post-COVID-19 pulmonary fibrosis. Some studies have shown promising results for nintedanib while results from several large ongoing clinical trials are awaited. Use of nintedanib in post-COVID-19 pulmonary fibrosis is promising based on the preliminary evidence from the present studies. However, the current evidence is limited and more evidence is awaited from the ongoing randomized clinical trials evaluating the safety and efficacy of nintedanib in the management of post-COVID-19 pulmonary fibrosis.

Key words: COVID-19; Pulmonary Fibrosis; Nintedanib


 
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How to Cite this Article
Pubmed Style

D S, Polavarapu S, Moram RS. A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 1-6. doi:10.5455/njppp.2023.13.05209202203062022


Web Style

D S, Polavarapu S, Moram RS. A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. https://www.njppp.com/?mno=36882 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.05209202203062022


AMA (American Medical Association) Style

D S, Polavarapu S, Moram RS. A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 1-6. doi:10.5455/njppp.2023.13.05209202203062022



Vancouver/ICMJE Style

D S, Polavarapu S, Moram RS. A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 1-6. doi:10.5455/njppp.2023.13.05209202203062022



Harvard Style

D, S., Polavarapu, . S. & Moram, . R. S. (2023) A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. Natl J Physiol Pharm Pharmacol, 13 (1), 1-6. doi:10.5455/njppp.2023.13.05209202203062022



Turabian Style

D, Shailendra, Sudheera Polavarapu, and Rajeev Sai Moram. 2023. A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 1-6. doi:10.5455/njppp.2023.13.05209202203062022



Chicago Style

D, Shailendra, Sudheera Polavarapu, and Rajeev Sai Moram. "A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1-6. doi:10.5455/njppp.2023.13.05209202203062022



MLA (The Modern Language Association) Style

D, Shailendra, Sudheera Polavarapu, and Rajeev Sai Moram. "A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 1-6. Print. doi:10.5455/njppp.2023.13.05209202203062022



APA (American Psychological Association) Style

D, S., Polavarapu, . S. & Moram, . R. S. (2023) A review on post-COVID-19 pulmonary fibrosis and the role of nintedanib in its management. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 1-6. doi:10.5455/njppp.2023.13.05209202203062022