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2023, Vol: 13, Issue: 9
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Original Research 


Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures

Raina Jain, Neeraj Khare, Ashish Jain.

Abstract
Background: Epilepsy is an abnormal excessive electric neuronal activity and always represents by recurrent seizures. There is positive feedback cycle between epileptogenesis and brain inflammation. It has been proved that an inflammatory enzyme, cyclooxygenase (COX) (especially isoform-2, a constitutive enzyme), expressed in some important parts of the central nervous system and is responsible to induced inflammation locally and having seizurogenic property.

Aim and Objective: The goal of this study was to see if celecoxib (a selective COX-2 inhibitor) could reduce the maximal electroshock seizure (MES)-induced seizures in mice.

Materials and Methods: Celecoxib injected intraperitoneally in two different doses 5 mg/kgb/w and 10 mg/kg b/w, in albino Swiss mice and in two different phases. MES was elicited and length of different phases was noted. Length of tonic hindlimb extension was considered as indicator of anti-epileptic activity.

Results: Celecoxib, when given intraperitoneally, exert significant reduction in the duration of THLE. This action of celecoxib strongly suggests the involvement of inflammation in the pathophysiology of epilepsy.

Conclusion: The findings are suggestive of the therapeutic significance of celecoxib, as a future antiepileptic agent for seizure management.

Key words: Epilepsy; Inflammation; Cyclooxygenase-2 Inhibitors; Celecoxib; Maximal Electroshock Seizure; THLE


 
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Pubmed Style

Jain R, Khare N, Jain A. Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 282-285. doi:10.5455/njppp.2023.13.05203202222062022

Web Style

Jain R, Khare N, Jain A. Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. https://www.njppp.com/?mno=34792 [Access: September 03, 2023]. doi:10.5455/njppp.2023.13.05203202222062022

AMA (American Medical Association) Style

Jain R, Khare N, Jain A. Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 282-285. doi:10.5455/njppp.2023.13.05203202222062022


Vancouver/ICMJE Style

Jain R, Khare N, Jain A. Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. Natl J Physiol Pharm Pharmacol. (2023), [cited September 03, 2023]; 13(2): 282-285. doi:10.5455/njppp.2023.13.05203202222062022


Harvard Style

Jain, R., Khare, . N. & Jain, . A. (2023) Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. Natl J Physiol Pharm Pharmacol, 13 (2), 282-285. doi:10.5455/njppp.2023.13.05203202222062022


Turabian Style

Jain, Raina, Neeraj Khare, and Ashish Jain. 2023. Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 282-285. doi:10.5455/njppp.2023.13.05203202222062022


Chicago Style

Jain, Raina, Neeraj Khare, and Ashish Jain. "Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 282-285. doi:10.5455/njppp.2023.13.05203202222062022


MLA (The Modern Language Association) Style

Jain, Raina, Neeraj Khare, and Ashish Jain. "Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 282-285. Print. doi:10.5455/njppp.2023.13.05203202222062022


APA (American Psychological Association) Style

Jain, R., Khare, . N. & Jain, . A. (2023) Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 282-285. doi:10.5455/njppp.2023.13.05203202222062022


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