An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital

Shrinivas R Raikar; Shivaraj B Patil; Venkata Rao Y; Raghuveer B

doi:10.5455/njppp.2018.8.0620811072018

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Original Research
Online Published: 20 Jul 2018

Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1405-1408

doi: 10.5455/njppp.2018.8.0620811072018

An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital

Shrinivas R Raikar, Shivaraj B Patil, Venkata Rao Y, Raghuveer B.

Cited By:3

Abstract
Background: Adverse drug reactions (ADRs) can lead to non-adherence to antiretroviral therapy (ART) and are also the major causes of hospitalization and higher cost of treatment.

Aims and Objectives: The aims of this study were to analyze the pattern of ADRs, causality, and severity among HIV-infected patients.

Materials and Methods: It was a retrospective analysis conducted over 1 year from January 2017 to December 2017. ADRs due to antiretroviral drugs (ARVs) were collected from the Government District Hospital, Nalgonda, as part of pharmacovigilance program and analyzed. The WHO-UMC scale was used for assessing the causality and HartwigSiegel scale for severity of reactions.

Results: A total of 113 ADRs due to ART were received. In that 68 were female patients. 83% ADRs were of mild grade of severity. Most of the ADRs were related to gastrointestinal system. Causality assessment of ADRs was probable in 62(54.9%) patients and possible in 51 (45.1%) patients.

Conclusion: Maximum number of ADRs was of mild nature suggesting that the ART is well tolerated among the patients. Further studies need to be conducted to fully understand the determinants of ADRs due to ART in a statistically significant manner.

Key words: Adverse Drug Reactions; Antiretroviral Therapy; Human Immunodeficiency Virus; Pharmacovigilance

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Pubmed Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

Web Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. https://www.njppp.com/?mno=301737 [Access: May 06, 2025]. doi:10.5455/njppp.2018.8.0620811072018

AMA (American Medical Association) Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

Vancouver/ICMJE Style

Raikar SR, Patil SB, Y VR, B R. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol. (2018), [cited May 06, 2025]; 8(10): 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

Harvard Style

Raikar, S. R., Patil, . S. B., Y, . V. R. & B, . R. (2018) An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. Natl J Physiol Pharm Pharmacol, 8 (10), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

Turabian Style

Raikar, Shrinivas R, Shivaraj B Patil, Venkata Rao Y, and Raghuveer B. 2018. An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

Chicago Style

Raikar, Shrinivas R, Shivaraj B Patil, Venkata Rao Y, and Raghuveer B. "An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

MLA (The Modern Language Association) Style

Raikar, Shrinivas R, Shivaraj B Patil, Venkata Rao Y, and Raghuveer B. "An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital." National Journal of Physiology, Pharmacy and Pharmacology 8.10 (2018), 1405-1408. Print. doi:10.5455/njppp.2018.8.0620811072018

APA (American Psychological Association) Style

Raikar, S. R., Patil, . S. B., Y, . V. R. & B, . R. (2018) An assessment of adverse reactions to antiretroviral therapy in a South Indian government hospital. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1405-1408. doi:10.5455/njppp.2018.8.0620811072018

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