E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India

Arijit Kayal, Pragnadyuti Mandal, Souvik Majumder, Animesh Maiti, Dipak Kumar Sarkar, Indranil Biswas.

Abstract
Background: The treatment of Type 2 diabetes mellitus (T2DM) requires many classes of drugs, combination of old and new drugs is usually recommended for intensification of therapies. Antidiabetic drug (ADD) utilization study promotes rational use of ADDs and reveals the recent trends in use.

Aims and Objectives: The objective of the study was to analyze drug utilization pattern with particular attention to initiation and intensification of the treatment options in T2DM patients of a diabetes clinic run by endocrinology department of a tertiary care teaching hospital in Eastern India.

Materials and Methods: This was a cross-sectional and observational study conducted at the diabetes clinic of a tertiary care Medical College and Hospital of West Bengal over a period of 12 months. After obtaining informed consent, diagnosed adult Type 2 diabetes patients receiving any ADD were included in the study. Demographic, clinical, and laboratory data, proportion of each class of ADDs, and WHO core drug use indicators were analyzed.

Results: A total of 298 patients ([167, 56%] males and [131, 44%] females) were enrolled. The mean age of the patients was 52.33 ± 9.91. Metformin (287/298, 96%) was the most commonly prescribed drug, followed by glimepiride (168/298, 56.38%), insulins (116/298, 38.93%), DPP4 inhibitors (108/298, 36.24%), and pioglitazone (99/298, 33.22%). Metformin, glimepiride (53/109, 48.62%) and metformin, glimepiride, and pioglitazone (36/113, 31.86%) were the common dual and triple drug combinations.

Conclusion: In Type 2 diabetes, metformin was the preferred agent for initiation of the treatment; glimepiride, insulin, DPP-4is, and pioglitazone were used in combination of metformin for intensification of therapy, consistent with current clinical practice guidelines.

Key words: Antidiabetic Drugs; Drug Utilization; Prescription Audit


 
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How to Cite this Article
Pubmed Style

Kayal A, Mandal P, Majumder S, Maiti A, Sarkar DK, Biswas I. Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022


Web Style

Kayal A, Mandal P, Majumder S, Maiti A, Sarkar DK, Biswas I. Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. https://www.njppp.com/?mno=28552 [Access: February 02, 2023]. doi:10.5455/njppp.2022.12.03122202204042022


AMA (American Medical Association) Style

Kayal A, Mandal P, Majumder S, Maiti A, Sarkar DK, Biswas I. Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022



Vancouver/ICMJE Style

Kayal A, Mandal P, Majumder S, Maiti A, Sarkar DK, Biswas I. Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. Natl J Physiol Pharm Pharmacol. (2022), [cited February 02, 2023]; 12(12): 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022



Harvard Style

Kayal, A., Mandal, . P., Majumder, . S., Maiti, . A., Sarkar, . D. K. & Biswas, . I. (2022) Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. Natl J Physiol Pharm Pharmacol, 12 (12), 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022



Turabian Style

Kayal, Arijit, Pragnadyuti Mandal, Souvik Majumder, Animesh Maiti, Dipak Kumar Sarkar, and Indranil Biswas. 2022. Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022



Chicago Style

Kayal, Arijit, Pragnadyuti Mandal, Souvik Majumder, Animesh Maiti, Dipak Kumar Sarkar, and Indranil Biswas. "Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022



MLA (The Modern Language Association) Style

Kayal, Arijit, Pragnadyuti Mandal, Souvik Majumder, Animesh Maiti, Dipak Kumar Sarkar, and Indranil Biswas. "Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 1988-1994. Print. doi:10.5455/njppp.2022.12.03122202204042022



APA (American Psychological Association) Style

Kayal, A., Mandal, . P., Majumder, . S., Maiti, . A., Sarkar, . D. K. & Biswas, . I. (2022) Trends in antidiabetic drug utilization in Type 2 diabetes patients in a diabetes clinic of a tertiary care teaching hospital in India. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 1988-1994. doi:10.5455/njppp.2022.12.03122202204042022