E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 10
14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research
Online Published: 17 Nov 2017
 


Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II.


Abstract
Background: Hyperuricemia and diseases related to hyperuricemia have been recognized among Filipinos in different countries. Diseases related to hyperuricemia such as gout and increased risks of cardiovascular diseases have given an avenue for methods on lowering uric acid levels. Aims and Objectives: Manilkara zapota, commonly known as Chico, has been reported to have the potential to reduce the uric acid level and thus was tested using aqueous leaf extracts of the plant.

Materials and Methods: The plant was administered at a low dose of 1g/kg body weight (BW) and a high dose of 3g/kg BW on 10–16-week-old male ICR mice for 28 days. Three control groups were used for comparison of results: The sham group was administered with sterile distilled water and was not treated with KBrO3, a positive control group was administered with ascorbic acid instead of the leaf extract and was treated with KBrO3, and a negative control group was administered with sterile water and was also treated with KBrO3. Hyperuricemia was induced using KBrO3 on the last day to detect for uric acid lowering activity.

Results: Analysis shows that the negative control group had the highest mean of uric acid levels after hyperuricemia induction resulting to a significant difference from among the other groups. The mean uric acid levels of the groups treated with the leaf extract and ascorbic acid after hyperuricemia induction did not have any significant difference from each other.

Conclusion: There is a urate-lowering activity from Manilkara zapota aqueous leaf extracts that are possibly due to the presence of flavonoids.

Key words: Anti-uricemic; Blood Uric Acid; Manilkara zapota; Mus musculus


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Maria Gabriela G Cervero
Articles by James Ellard D Sy
Articles by Michael B Ples
Articles by Rodel Jonathan S Vitor II
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. Natl J Physiol Pharm Pharmacol. 2018; 8(3): 426-430. doi:10.5455/njppp.2017.7.1039309112017

Web Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. https://www.njppp.com/?mno=280008 [Access: October 03, 2024]. doi:10.5455/njppp.2017.7.1039309112017

AMA (American Medical Association) Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. Natl J Physiol Pharm Pharmacol. 2018; 8(3): 426-430. doi:10.5455/njppp.2017.7.1039309112017


Vancouver/ICMJE Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. Natl J Physiol Pharm Pharmacol. (2018), [cited October 03, 2024]; 8(3): 426-430. doi:10.5455/njppp.2017.7.1039309112017


Harvard Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II (2018) Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. Natl J Physiol Pharm Pharmacol, 8 (3), 426-430. doi:10.5455/njppp.2017.7.1039309112017


Turabian Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. 2018. Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. National Journal of Physiology, Pharmacy and Pharmacology, 8 (3), 426-430. doi:10.5455/njppp.2017.7.1039309112017


Chicago Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. "Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 426-430. doi:10.5455/njppp.2017.7.1039309112017


MLA (The Modern Language Association) Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II. "Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia." National Journal of Physiology, Pharmacy and Pharmacology 8.3 (2018), 426-430. Print. doi:10.5455/njppp.2017.7.1039309112017


APA (American Psychological Association) Style

Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II (2018) Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia. National Journal of Physiology, Pharmacy and Pharmacology, 8 (3), 426-430. doi:10.5455/njppp.2017.7.1039309112017




Most Viewed Articles
Most Accessed Articles

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract » doi: 10.5455/njppp.2013.3.109-114

    •
    Most Downloaded
    Top Downloaded Articles

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract » doi: 10.5455/njppp.2011.1.1-8

    •
    Most Cited Articles
    Most Cited Articles

    About National Journal of Physiology, Pharmacy and Pharmacology

      National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Eldaghayes Publisher

    www.eldagpublisher.com 

     
    All correspondence should be addressed to:
    Prof. Ibrahim Eldaghayes
    Editor-in-Chief
    National Journal of Physiology, Pharmacy and Pharmacology
    Email: ibrahim.eldaghayes@vetmed.edu.ly
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use