Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study

Ashwini Kishan; Shailaja S Moodithaya; Amrit M Mirajkar

doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

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Original Research
Online Published: 23 May 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(10): 1009-1013

doi: Perimenopause;MenopausalTransitionSymptoms;Estrogen

Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study

Ashwini Kishan, Shailaja S Moodithaya, Amrit M Mirajkar.

Abstract
Background: Menopause is a gradual transition from reproductive to non-reproductive phase in women during which there is substantial fluctuation in estrogen or estrogen deficiency. Furthermore, women encounter various psychological, physical symptoms during this transition period. Timely diagnosis can result in appropriate interventions to reduce these symptoms and result in uneventful transition period.

Aims and Objectives: To evaluate the association between psychological symptoms during menopausal transition period and serum estrogen levels.

Materials and Methods: Seventy-five women volunteers in the age group of 45-60 years (perimenopausal (PM) with symptoms, PM without symptoms, PM women - 25 in each group) were evaluated for symptoms of menopausal transition using Women Health Questionnaire. Serum estrogen level was estimated by enzyme-linked immunosorbent assay method.

Results: The study showed that there was a significant difference in psychological stress levels quantified as stress scores among three groups, with symptomatic PM women having much higher stress levels compared to other groups. Correlation statistics showed that there was a significant correlation between serum estrogen levels and psychological stress level. There was a significant correlation between anxiety depression mood disturbances, vasomotor symptoms, and symptoms of well-being with serum estrogen level.

Conclusions: The symptoms of menopausal transition are attributed to reduction in estrogen level. These symptoms lead to substantial psychological stress among women during PM transition period.

Key words: Perimenopause; Menopausal Transition Symptoms; Estrogen

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Pubmed Style

Kishan A, Moodithaya SS, Mirajkar AM. Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2017; 7(10): 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

Web Style

Kishan A, Moodithaya SS, Mirajkar AM. Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. https://www.njppp.com/?mno=266211 [Access: June 01, 2025]. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

AMA (American Medical Association) Style

Kishan A, Moodithaya SS, Mirajkar AM. Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2017; 7(10): 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

Vancouver/ICMJE Style

Kishan A, Moodithaya SS, Mirajkar AM. Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2017), [cited June 01, 2025]; 7(10): 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

Harvard Style

Kishan, A., Moodithaya, . S. S. & Mirajkar, . A. M. (2017) Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. Natl J Physiol Pharm Pharmacol, 7 (10), 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

Turabian Style

Kishan, Ashwini, Shailaja S Moodithaya, and Amrit M Mirajkar. 2017. Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (10), 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

Chicago Style

Kishan, Ashwini, Shailaja S Moodithaya, and Amrit M Mirajkar. "Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

MLA (The Modern Language Association) Style

Kishan, Ashwini, Shailaja S Moodithaya, and Amrit M Mirajkar. "Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 7.10 (2017), 1009-1013. Print. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

APA (American Psychological Association) Style

Kishan, A., Moodithaya, . S. S. & Mirajkar, . A. M. (2017) Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (10), 1009-1013. doi:Perimenopause;MenopausalTransitionSymptoms;Estrogen

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