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Original Research
Online Published: 27 Jul 2012
 


Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats

Shirish Joshi, Urmila Thatte.


Abstract
Background: Most of the currently available therapies for peptic ulcer disease have their own limitations and an ideal therapeutic agent is not yet available in the market.Hence,we decided to explore the cytoprotective potential of Indian Medicinal Plants namely Phyllanthus emblica and Asparagus racemosus along with ranitidine as a positive control in various animal models.

Aims & Objective: To evaluate the cytoprotective effect of the extracts of Phyllanthus emblica (PE) and Asparagus racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats.

Materials and Methods: Cold immobilization stress, ethanol (99.9%), aspirin were the experimental models selected for inducing gastric erosions and ulcerations. Ulcer index , erosions, oedema, congestion and inflammation were the parameters studied for assessing gastric damage whereas carrageenininduced rat paw oedema model was used to induce inflammation.Ranitidine was used as a positive control.

Results: The two drugs chosen for the study namely Phyllanthus emblica and Asparagus racemosus prevented gastric damage significantly in the ethanol group (p<0.05) and cold stress group (p<0.05). In the aspirin group, erosions, oedema, congestion and inflammation were remarkably reduced by PE cold water extract (PECWE) and PE hot water extract (PEHWE) and in the AR treated groups when compared with the control group. PECWE and PEHWE showed significant anti-inflammatory activity (p<0.05) comparable to aspirin thereby proving their role in inflammatory disorders. In our study, AR also showed a significant protection (p<0.05) against ethanol, cold stress and aspirin group.

Conclusion: The present study supports that ethanol, cold simmobilization stress and aspirin induce gastritis, gastric erosions and ulcerations and Phyllanthus emblica and Asparagus racemosus have significant potential as prominent cytoprotectants against these toxic effects.<i></i><i></i><i></i><i></i>

Key words: Ulcer Index, Inflammation, Paw Oedema


 
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Pubmed Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol. 2012; 2(2): 172-178. doi:10.5455/njppp.2012.2.172-178

Web Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. https://www.njppp.com/?mno=23766 [Access: September 12, 2024]. doi:10.5455/njppp.2012.2.172-178

AMA (American Medical Association) Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol. 2012; 2(2): 172-178. doi:10.5455/njppp.2012.2.172-178


Vancouver/ICMJE Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol. (2012), [cited September 12, 2024]; 2(2): 172-178. doi:10.5455/njppp.2012.2.172-178


Harvard Style

Shirish Joshi, Urmila Thatte (2012) Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol, 2 (2), 172-178. doi:10.5455/njppp.2012.2.172-178


Turabian Style

Shirish Joshi, Urmila Thatte. 2012. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. National Journal of Physiology, Pharmacy and Pharmacology, 2 (2), 172-178. doi:10.5455/njppp.2012.2.172-178


Chicago Style

Shirish Joshi, Urmila Thatte. "Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats." National Journal of Physiology, Pharmacy and Pharmacology 2 (2012), 172-178. doi:10.5455/njppp.2012.2.172-178


MLA (The Modern Language Association) Style

Shirish Joshi, Urmila Thatte. "Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats." National Journal of Physiology, Pharmacy and Pharmacology 2.2 (2012), 172-178. Print. doi:10.5455/njppp.2012.2.172-178


APA (American Psychological Association) Style

Shirish Joshi, Urmila Thatte (2012) Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. National Journal of Physiology, Pharmacy and Pharmacology, 2 (2), 172-178. doi:10.5455/njppp.2012.2.172-178




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