Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study

Trilok Ranjan Srivastava; Ranjan Kumar Dixit

doi:10.5455/njppp.2017.7.0512210082016

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Original Research
Online Published: 31 Aug 2016

Natl J Physiol Pharm Pharmacol. 2017; 7(2): 170-173

doi: 10.5455/njppp.2017.7.0512210082016

Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study

Trilok Ranjan Srivastava, Ranjan Kumar Dixit.

Cited By:3

Abstract
Background: The studies have reported that high serum uric acid (UA) and low nitric oxide (NO) levels are strongly associated with prevalent health conditions such as obesity, insulin resistance, metabolic syndrome, diabetes, essential hypertension, and renal disease. None of the studies have examined the predictive value of serum UA and NO in the diagnosis of Type 2 diabetes, especially from India.

Aims and Objectives: To find out the predictive value of serum UA and NO in the diagnosis of Type 2 diabetes.

Materials and Methods: This was a casecontrol study. A total of 40 cases of Type 2 diabetes were included (20 male and 20 female). Age- and sex-matched apparently healthy subjects (n = 40) without any history or symptoms of diabetes and other metabolic disorders were chosen as the control (20 male and 20 female).

Results: The serum UA was significantly (P = 0.0001) higher among the cases (16.23 ± 2.89) compared to controls (11.77 ± 5.92). However, NO was found to be significantly lower among the cases (47.33 ± 10.70) than controls (61.19 ± 10.48). The sensitivity and specificity of serum UA were 62.5% and 57.5%, respectively, with a cutoff value of 15.75. A moderate area under the curve (AUC) was found which was statistically significant. A reasonable sensitivity (70%) and specificity (77.5%) of NO were also observed, however, AUC was small.

Conclusion: We found moderate sensitivity and specificity of serum UA and NO in the diagnosis of Type 2 diabetes.

Key words: Type 2 Diabetes; Serum Uric Acid; Serum Nitric Oxide; Sensitivity; Specificity

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Pubmed Style

Srivastava TR, Dixit RK. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 170-173. doi:10.5455/njppp.2017.7.0512210082016

Web Style

Srivastava TR, Dixit RK. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. https://www.njppp.com/?mno=228214 [Access: May 07, 2025]. doi:10.5455/njppp.2017.7.0512210082016

AMA (American Medical Association) Style

Srivastava TR, Dixit RK. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 170-173. doi:10.5455/njppp.2017.7.0512210082016

Vancouver/ICMJE Style

Srivastava TR, Dixit RK. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. Natl J Physiol Pharm Pharmacol. (2017), [cited May 07, 2025]; 7(2): 170-173. doi:10.5455/njppp.2017.7.0512210082016

Harvard Style

Srivastava, T. R. & Dixit, . R. K. (2017) Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. Natl J Physiol Pharm Pharmacol, 7 (2), 170-173. doi:10.5455/njppp.2017.7.0512210082016

Turabian Style

Srivastava, Trilok Ranjan, and Ranjan Kumar Dixit. 2017. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 170-173. doi:10.5455/njppp.2017.7.0512210082016

Chicago Style

Srivastava, Trilok Ranjan, and Ranjan Kumar Dixit. "Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 170-173. doi:10.5455/njppp.2017.7.0512210082016

MLA (The Modern Language Association) Style

Srivastava, Trilok Ranjan, and Ranjan Kumar Dixit. "Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study." National Journal of Physiology, Pharmacy and Pharmacology 7.2 (2017), 170-173. Print. doi:10.5455/njppp.2017.7.0512210082016

APA (American Psychological Association) Style

Srivastava, T. R. & Dixit, . R. K. (2017) Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus - A casecontrol study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 170-173. doi:10.5455/njppp.2017.7.0512210082016

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