Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide

Mbaye Sene; Ibrahima Diouf; Mamadou Ndiaye; Awa Ba; Awa Ndiaye; Modou Oumy Kane; Mamadou Sarr; Valérie Schini-Kerth; Madieye Sene

doi:10.5455/NJPPP.2025.v15.i3.6

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Natl J Physiol Pharm Pharmacol. 2025; 15(3): 253-257

doi: 10.5455/NJPPP.2025.v15.i3.6

Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide

Mbaye Sene, Ibrahima Diouf, Mamadou Ndiaye, Awa Ba, Awa Ndiaye, Modou Oumy Kane, Mamadou Sarr, Valérie Schini-kerth, Madieye Sene.

Abstract
Background:
Elaeis guineensis is a plant of the Arecaceae family that is used in traditional medicine in Senegal to treat high blood pressure. However, to our knowledge, there is no scientific evidence supporting its ability to lower blood pressure in hypertensive patients.

Aim:
The objective of this study was to provide a scientific basis for the use of this plant as a remedy for high blood pressure in traditional medicine.

Methods:
We in vitro evaluated the endothelium-dependent vasorelaxant capacity of a methanolic fraction of E. guineensis leaf powder (MSEG01). To achieve this, rings of pig coronary arteries with and without endothelium are mounted in isolated organ chambers. After stabilization for approximately 1 hour, the rings were precontracted with U46619 and then exposed to a range of increasing concentrations of MSEG01 ranging from 1 to 100 μg/ml. For some experiments, the rings were incubated with different inhibitors (L-NA, INDOMETHACIN, TRAM-34 +UCL) to determine the cell signaling pathways involved in MSEG01-induced relaxation.

Results:
The results showed that MSEG01 causes relaxation in a model of coronary arteries in pigs previously contracted with U46619. For rings with endothelium, a relaxation start was noted at 3 μg/ml, and the maximum relaxation (90%) was obtained at 100 μg/ml. Without endothelium, MSEG01 does not induce relaxation.

Conclusion:
This study explains the use of E. guineensis for the management and prevention of high blood pressure and cardiovascular complications in traditional medicine in Senegal. However, additional research is needed to ensure its safety for human health.

Key words: Elaeis guineensis, Vasorelaxant effects, Porcine coronary

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How to Cite this Article

Pubmed Style

Sene M, Diouf I, Ndiaye M, Ba A, Ndiaye A, Kane MO, Sarr M, Schini-kerth V, Sene M. Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. Natl J Physiol Pharm Pharmacol. 2025; 15(3): 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

Web Style

Sene M, Diouf I, Ndiaye M, Ba A, Ndiaye A, Kane MO, Sarr M, Schini-kerth V, Sene M. Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. https://www.njppp.com/?mno=225940 [Access: April 17, 2025]. doi:10.5455/NJPPP.2025.v15.i3.6

AMA (American Medical Association) Style

Sene M, Diouf I, Ndiaye M, Ba A, Ndiaye A, Kane MO, Sarr M, Schini-kerth V, Sene M. Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. Natl J Physiol Pharm Pharmacol. 2025; 15(3): 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

Vancouver/ICMJE Style

Sene M, Diouf I, Ndiaye M, Ba A, Ndiaye A, Kane MO, Sarr M, Schini-kerth V, Sene M. Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. Natl J Physiol Pharm Pharmacol. (2025), [cited April 17, 2025]; 15(3): 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

Harvard Style

Sene, M., Diouf, . I., Ndiaye, . M., Ba, . A., Ndiaye, . A., Kane, . M. O., Sarr, . M., Schini-kerth, . V. & Sene, . M. (2025) Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. Natl J Physiol Pharm Pharmacol, 15 (3), 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

Turabian Style

Sene, Mbaye, Ibrahima Diouf, Mamadou Ndiaye, Awa Ba, Awa Ndiaye, Modou Oumy Kane, Mamadou Sarr, Valérie Schini-kerth, and Madieye Sene. 2025. Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. National Journal of Physiology, Pharmacy and Pharmacology, 15 (3), 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

Chicago Style

Sene, Mbaye, Ibrahima Diouf, Mamadou Ndiaye, Awa Ba, Awa Ndiaye, Modou Oumy Kane, Mamadou Sarr, Valérie Schini-kerth, and Madieye Sene. "Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide." National Journal of Physiology, Pharmacy and Pharmacology 15 (2025), 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Sene, M., Diouf, . I., Ndiaye, . M., Ba, . A., Ndiaye, . A., Kane, . M. O., Sarr, . M., Schini-kerth, . V. & Sene, . M. (2025) Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide. National Journal of Physiology, Pharmacy and Pharmacology, 15 (3), 253-257. doi:10.5455/NJPPP.2025.v15.i3.6

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