Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection

Nesriene El-Margoushy; Ahmed M. A. Mansour; Nihad El-Nashar; Manal El-Nashar; Tamer Askar

doi:10.5455/njppp.2016.6.20160409224042016

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Original Research
Online Published: 31 Aug 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(5): 376-380

doi: 10.5455/njppp.2016.6.20160409224042016

Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection

Nesriene El-margoushy, Ahmed M. A. Mansour, Nihad El-nashar, Manal El-nashar, Tamer Askar.

Cited By:1

Abstract
Background: Asthma and chronic obstructive pulmonary disease (COPD) are characterized by a progressive airflow limitation. COPD is considered the fourth leading cause of death worldwide. Helicobacter pylori is a Gram-negative bacteria are closely associated with peptic ulcer development.

Aims and Objectives: This study aimed to compare the incidence of peptic ulcer disease between asthmatic and COPD group of patients and evaluation of its relation to H. pylori infection.

Materials and Methods: This study includes 50 patients with COPD from both sexes (M: 35/F:15), 50 patients with bronchial asthma from both sexes (M: 30/F: 20) from King Abdul-Aziz Hospital, Taif area, and 25 healthy control volunteers (M: 17/F: 8) matched in age and sex. Total immunoglobulin E (IgE), pH, pO2, pCO2, forced vital capacity (FVC), forced expiratory volume in first second (FEV1)/FVC, and forced expiratory flow (FEF) 25-75 were measured and matched between various groups.

Results: Total serum IgE T-IgE showed a non-significant increase in COPD patients compared to control (68.33 ± 16.74) while it increased significantly in asthmatic patients (243.65 ± 120.54) compared to control. Regarding pH, pO2, and pCO2 relation between control and asthmatic patients, the results are non-significant while it was significant (P < 0.05) for pH between control and COPD patients and was highly significant (P < 0.001) for pO2 and pCO2 in the two groups. For FVC, FEV1/FVC, and FEF 25-75 between control and asthma patients, results considered highly significant (P < 0.001) while it showed a significant difference (P < 0.05) for FEV1 in both groups. For FVC, FEV1/FVC, and FEF 25-75 between control and COPD patients, the results are considered highly significant (P < 0.001), and a very highly significant difference (P < 0.05) for control and COPD.

Conclusion: Close interaction between the incidence of peptic ulcer disease with asthma and COPD group of patients in relation to H. pylori infection was confirmed.

Key words: Peptic Ulcer; Chronic Obstructive Pulmonary Disease; Bronchial Asthma; Helicobacter pylori Infection

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How to Cite this Article

Pubmed Style

El-margoushy N, Mansour AMA, El-nashar N, El-nashar M, Askar T. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol. 2016; 6(5): 376-380. doi:10.5455/njppp.2016.6.20160409224042016

Web Style

El-margoushy N, Mansour AMA, El-nashar N, El-nashar M, Askar T. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. https://www.njppp.com/?mno=224840 [Access: November 02, 2025]. doi:10.5455/njppp.2016.6.20160409224042016

AMA (American Medical Association) Style

El-margoushy N, Mansour AMA, El-nashar N, El-nashar M, Askar T. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol. 2016; 6(5): 376-380. doi:10.5455/njppp.2016.6.20160409224042016

Vancouver/ICMJE Style

El-margoushy N, Mansour AMA, El-nashar N, El-nashar M, Askar T. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol. (2016), [cited November 02, 2025]; 6(5): 376-380. doi:10.5455/njppp.2016.6.20160409224042016

Harvard Style

El-margoushy, N., Mansour, . A. M. A., El-nashar, . N., El-nashar, . M. & Askar, . T. (2016) Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol, 6 (5), 376-380. doi:10.5455/njppp.2016.6.20160409224042016

Turabian Style

El-margoushy, Nesriene, Ahmed M. A. Mansour, Nihad El-nashar, Manal El-nashar, and Tamer Askar. 2016. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. National Journal of Physiology, Pharmacy and Pharmacology, 6 (5), 376-380. doi:10.5455/njppp.2016.6.20160409224042016

Chicago Style

El-margoushy, Nesriene, Ahmed M. A. Mansour, Nihad El-nashar, Manal El-nashar, and Tamer Askar. "Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 376-380. doi:10.5455/njppp.2016.6.20160409224042016

MLA (The Modern Language Association) Style

El-margoushy, Nesriene, Ahmed M. A. Mansour, Nihad El-nashar, Manal El-nashar, and Tamer Askar. "Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection." National Journal of Physiology, Pharmacy and Pharmacology 6.5 (2016), 376-380. Print. doi:10.5455/njppp.2016.6.20160409224042016

APA (American Psychological Association) Style

El-margoushy, N., Mansour, . A. M. A., El-nashar, . N., El-nashar, . M. & Askar, . T. (2016) Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. National Journal of Physiology, Pharmacy and Pharmacology, 6 (5), 376-380. doi:10.5455/njppp.2016.6.20160409224042016

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