Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital

Hiren Jitendra Udhnawala; Nazima Mirza; Nirav Asarawala; Barna Ganguly

doi:10.5455/NJPPP.2025.v15.i2.3

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Natl J Physiol Pharm Pharmacol. 2025; 15(2): 128-136

doi: 10.5455/NJPPP.2025.v15.i2.3

Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital

Hiren Jitendra Udhnawala, Nazima Mirza, Nirav Asarawala, Barna Ganguly.

Abstract
Background:
Cisplatin is a commonly used chemotherapy agent for solid tumors, including lung, ovarian, testicular, bladder, and oral cancers. However, it can cause significant adverse drug reactions (ADRs).

Aim: Therefore, this study aimed to evaluate the experience of patients with cancer undergoing chemotherapy by estimating the number of ADRs
associated with cisplatin treatment.

Methods:
Prospective observational research was conducted in a hospital setting by the Department of Pharmacology in collaboration with the Department of Oncology in Shree Krishna Hospital, Karamsad, Anand, Gujarat, from February 18, 2023, to February 29, 2024. The study included 105 patients at the daycare center who were receiving cisplatin-based chemotherapy for the first time for solid cancer tumors. Sample size calculation was done based on the number of patients admitted to daycare for cisplatin treatment.

Results:
Of the 105 participants, most (70.48%) were male, with a mean age of 49.03 years; the majority of them were receiving treatment for malignancies of the buccal mucosa and oral cavity. Cisplatin was administered according to the protocol, with antiemetic and hydration measures to mitigate adverse effects. Nephrotoxicity, tinnitus, vomiting, hearing loss, and loss of taste were notable ADRs among the study participants.

Conclusion:
ADRs, such as vomiting, nephrotoxicity, tinnitus, and loss of taste, were noted at different frequencies during each cycle. Most of the studies were mild but not preventable, and they had no impact on the patients’ course of therapy.

Key words: Cisplatin, Adverse drug reaction (ADR)

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How to Cite this Article

Pubmed Style

Udhnawala HJ, Mirza N, Asarawala N, Ganguly B. Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2025; 15(2): 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

Web Style

Udhnawala HJ, Mirza N, Asarawala N, Ganguly B. Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. https://www.njppp.com/?mno=224783 [Access: March 08, 2025]. doi:10.5455/NJPPP.2025.v15.i2.3

AMA (American Medical Association) Style

Udhnawala HJ, Mirza N, Asarawala N, Ganguly B. Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2025; 15(2): 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

Vancouver/ICMJE Style

Udhnawala HJ, Mirza N, Asarawala N, Ganguly B. Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2025), [cited March 08, 2025]; 15(2): 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

Harvard Style

Udhnawala, H. J., Mirza, . N., Asarawala, . N. & Ganguly, . B. (2025) Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 15 (2), 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

Turabian Style

Udhnawala, Hiren Jitendra, Nazima Mirza, Nirav Asarawala, and Barna Ganguly. 2025. Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 15 (2), 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

Chicago Style

Udhnawala, Hiren Jitendra, Nazima Mirza, Nirav Asarawala, and Barna Ganguly. "Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 15 (2025), 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Udhnawala, H. J., Mirza, . N., Asarawala, . N. & Ganguly, . B. (2025) Range of adverse drug reactions in patients on cisplatin-based cancer chemotherapy in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 15 (2), 128-136. doi:10.5455/NJPPP.2025.v15.i2.3

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