Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes
Mellitus

Deepak N Parchwani; Jatin V Dhanani; Amit A Upadhyah; Manojkumar H Sharma; Amit M Shah; Pankaj B Maheria; Kamlesh M Palandurkar

doi:10.5455/njppp.2012.2.84-92

2026, Vol: 16, Issue: 1

16 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form
Title Page

« Previous Article

Original Research
Online Published: 25 Jun 2012

Natl J Physiol Pharm Pharmacol. 2012; 2(2): 84-92

doi: 10.5455/njppp.2012.2.84-92

Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus

Deepak N Parchwani, Jatin V Dhanani, Amit A Upadhyah, Manojkumar H Sharma, Amit M Shah, Pankaj B Maheria, Kamlesh M Palandurkar.

Cited By:6

Abstract
Background: Diabetic autonomic neuropathy is a serious and common complication of diabetes mellitus and in fact it is one of the most overlooked complications, thus very limited clinical and research data are available on early renal and cardiovascular autonomic complications in type 2 diabetes mellitus.

Aims & Objective: To determine the possible association of elevated albumin excretion rate with cardiovascular autonomic activity in type 2 diabetes mellitus.

Materials and methods: A cross-sectional study was conducted with one hundred and fifteen patients of type 2 diabetes mellitus. Microalbuminuria was defined as Albumin Excretion Rate (AER) > 30 mg/24 hr in an early morning urine sample. Nine parameters reflecting different aspects of cardiovascular autonomic function were measured and were summarized in a single cardiovascular autonomic function score (CAFS).The association between cardiovascular autonomic dysfunction and microalbuminuria was estimated by multiple linear regressions.

Results: Patients with microalbuminuria had low levels of the autonomic function parameters i.e. mean CAFS, indicating impaired autonomic function. This association was consistent with increasing AER, and remained significant after multivariate adjustment for other clinical factors predictive of microalbuminuria. In additional analysis, we examined the autonomic function tests combined on the part of autonomic nervous system they predominantly represent. The results of these alternative combinations were comparable to those of the CAFS score.

Conclusion: Cardiovascular autonomic dysfunction was independently associated with microalbuminuria in patients with type 2 diabetes mellitus, and that this association is independent of other previously identified determinants of albuminuria in type 2 diabetes mellitus. Therefore cardiovascular autonomic function tests should be monitored to pay attention to major potential cardiovascular complications even in asymptomatic patients, but especially among those with microalbuminuria.

Key words: Microalbuminuria; Cardiovascular Autonomic Function Tests; Type 2 Diabetes Mellitus

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Deepak N Parchwani Articles by Jatin V Dhanani Articles by Amit A Upadhyah Articles by Manojkumar H Sharma Articles by Amit M Shah Articles by Pankaj B Maheria Articles by Kamlesh M Palandurkar
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Parchwani DN, Dhanani JV, Upadhyah AA, Sharma MH, Shah AM, Maheria PB, Palandurkar KM. Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. Natl J Physiol Pharm Pharmacol. 2012; 2(2): 84-92. doi:10.5455/njppp.2012.2.84-92

Web Style

Parchwani DN, Dhanani JV, Upadhyah AA, Sharma MH, Shah AM, Maheria PB, Palandurkar KM. Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. https://www.njppp.com/?mno=22110 [Access: November 02, 2025]. doi:10.5455/njppp.2012.2.84-92

AMA (American Medical Association) Style

Parchwani DN, Dhanani JV, Upadhyah AA, Sharma MH, Shah AM, Maheria PB, Palandurkar KM. Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. Natl J Physiol Pharm Pharmacol. 2012; 2(2): 84-92. doi:10.5455/njppp.2012.2.84-92

Vancouver/ICMJE Style

Parchwani DN, Dhanani JV, Upadhyah AA, Sharma MH, Shah AM, Maheria PB, Palandurkar KM. Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. Natl J Physiol Pharm Pharmacol. (2012), [cited November 02, 2025]; 2(2): 84-92. doi:10.5455/njppp.2012.2.84-92

Harvard Style

Parchwani, D. N., Dhanani, . J. V., Upadhyah, . A. A., Sharma, . M. H., Shah, . A. M., Maheria, . P. B. & Palandurkar, . K. M. (2012) Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. Natl J Physiol Pharm Pharmacol, 2 (2), 84-92. doi:10.5455/njppp.2012.2.84-92

Turabian Style

Parchwani, Deepak N, Jatin V Dhanani, Amit A Upadhyah, Manojkumar H Sharma, Amit M Shah, Pankaj B Maheria, and Kamlesh M Palandurkar. 2012. Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 2 (2), 84-92. doi:10.5455/njppp.2012.2.84-92

Chicago Style

Parchwani, Deepak N, Jatin V Dhanani, Amit A Upadhyah, Manojkumar H Sharma, Amit M Shah, Pankaj B Maheria, and Kamlesh M Palandurkar. "Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus." National Journal of Physiology, Pharmacy and Pharmacology 2 (2012), 84-92. doi:10.5455/njppp.2012.2.84-92

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Parchwani, D. N., Dhanani, . J. V., Upadhyah, . A. A., Sharma, . M. H., Shah, . A. M., Maheria, . P. B. & Palandurkar, . K. M. (2012) Relationship between cardiovascular autonomic (dys)function and microalbuminuria in type 2 Diabetes Mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 2 (2), 84-92. doi:10.5455/njppp.2012.2.84-92

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article