Abstract
Background: At present, there are considerable scientific evidences to suggest that nutritive and non-nutritive plant-based dietary factors can inhibit the process of carcinogenesis effectively.

Aims and Objective: The aim of the present study was to use essential oils extracted by different methods from Achillea fragrantissima (hexane extract [HE] and oil extract [OE]) in the manufacture of soap, which can be used as anti-inflammatory agent.

Materials and Methods: The anti-inflammatory effect of volatile oil was studied using carrageenan induced paw edema method at 100 mg/kg dose orally. Furthermore, it also studies the chemical composition of Achillea extracts by GC-MS.

Results: This study demonstrated that extracts of Achillea fragrantissima have excellent anti-inflammatory properties. Of the two extracts analyzed by gas chromatographymass spectrometry (GC-MS), there were differences in the chemical composition of essential oil of two extracts. Bisabolol, bisabolol oxide, menthol, and b-caryophyllene are the major constituents of the Achillea extract, some compounds were found in OE and not found in HE. Conclusion: Our observations supports Achillea fragrantissima which is used by many
people in the northern region for medicinal uses, it is safe and it can be used as anti-inflammatory drug.

Key words: Anti-inflammatory; Natural Soap; Achillea fragrantissima