Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata

Vetriselvan Subramaniyan; Anil Middha

doi:10.5455/njppp.2016.6.24122015106

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Online Published: 27 Feb 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174

doi: 10.5455/njppp.2016.6.24122015106

Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata

Vetriselvan Subramaniyan, Anil Middha.

Cited By:22

Abstract
Background: Chronic alcohol consumption is a known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The present experimental model was evaluated with medicinal plant Boswellia serrata and the results reflected potential beneficial and reducing risk factors for liver disease.

Aims and Objectives: To determine the hepatoprotective activity of aqueous extract of Boswellia serrata. Chronic ethanol consumption is a major risk factor in determining liver disease and other metabolic syndrome via multiple mechanisms, including the regulation of the lipid metabolism.

Materials and Methods: Male Wistar rats were divided into 6 groups (n = 6/group), and fed with a standard diet, ethanol, and ethanol supplemented with extracts for 6 weeks. The ethanol changes were determined via a serum enzyme profile of the liver. Liver toxicity was assessed in terms such as, serum indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, total proteins, albumin, globulin, albumin: globulin ratio, and liver weight.

Results: Oral administration of 250 and 500 mg/kg of AEBS offered a significant (P < 0.01) dose-dependent protection against ethanol-induced hepatotoxicity.

Conclusion: This study revealed that aqueous extract of Boswellia serrata in phytochemical constituents plays an active role against enzymes elevation and protection of liver.

Key words: Boswellia serrata; Ethanol; Serum Enzymes; Hepatotoxicity; Hepatoprotective

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Pubmed Style

Subramaniyan V, Middha A. Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106

Web Style

Subramaniyan V, Middha A. Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. https://www.njppp.com/?mno=211692 [Access: November 01, 2025]. doi:10.5455/njppp.2016.6.24122015106

AMA (American Medical Association) Style

Subramaniyan V, Middha A. Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106

Vancouver/ICMJE Style

Subramaniyan V, Middha A. Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. (2016), [cited November 01, 2025]; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106

Harvard Style

Subramaniyan, V. & Middha, . A. (2016) Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106

Turabian Style

Subramaniyan, Vetriselvan, and Anil Middha. 2016. Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106

Chicago Style

Subramaniyan, Vetriselvan, and Anil Middha. "Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 170-174. doi:10.5455/njppp.2016.6.24122015106

MLA (The Modern Language Association) Style

Subramaniyan, Vetriselvan, and Anil Middha. "Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata." National Journal of Physiology, Pharmacy and Pharmacology 6.2 (2016), 170-174. Print. doi:10.5455/njppp.2016.6.24122015106

APA (American Psychological Association) Style

Subramaniyan, V. & Middha, . A. (2016) Chronic ethanol consumptioninduced hepatotoxicity and protective effect of Boswellia serrata. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106

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