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Original Research
Online Published: 12 Aug 2024
 


Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study

Jinal M Modh, Amita R Kubavat, Anil P Singh.


Abstract
Background: Patients with β-thalassemia major (TM) require lifelong blood transfusions, leading to iron overload, where active intervention is required.

Aims and Objectives: The aim of the study was to evaluate real-world efficacy and safety of deferasirox (DFX) in TM patients at a tertiary care teaching hospital.

Materials and Methods: A prospective observational study was conducted at thalassemia ward in a tertiary care teaching hospital in Gujarat for a period of 15 months from April 2021 to July 2022. A total of 100 patients were analyzed during the study period. Patient’s demographic profile, laboratory investigation, and treatment details were analyzed using descriptive statistics. Statistical analysis was done through the statistical software GraphPad Prism 9.4.1 (681).

Results: A total of 100 patients were included in the study. A serial significant decrease in median serum ferritin levels was observed in >13 years age group after initiation of DFX. A significant increase in the median dose of DFX was observed at 12 months in the age group of 2–≤13 years as compared to baseline (P < 0.05). Adverse reactions observed during the study were increased bilirubin level, increased alanine aminotransferase, and increased serum creatinine, rashes with itching, and arthralgia.

Conclusion: A greater reduction in median serum ferritin levels was observed in the adult age group compared to pediatric patients.

Key words: Thalassemia Major; Deferasirox; Iron Chelation; Safety; Serum Ferritin


 
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Pubmed Style

Modh JM, Kubavat AR, Singh AP. Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024

Web Style

Modh JM, Kubavat AR, Singh AP. Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. https://www.njppp.com/?mno=208262 [Access: October 03, 2024]. doi:10.5455/njppp.2024.13.072742024202082024

AMA (American Medical Association) Style

Modh JM, Kubavat AR, Singh AP. Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024


Vancouver/ICMJE Style

Modh JM, Kubavat AR, Singh AP. Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. Natl J Physiol Pharm Pharmacol. (2024), [cited October 03, 2024]; 14(10): 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024


Harvard Style

Modh, J. M., Kubavat, . A. R. & Singh, . A. P. (2024) Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. Natl J Physiol Pharm Pharmacol, 14 (10), 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024


Turabian Style

Modh, Jinal M, Amita R Kubavat, and Anil P Singh. 2024. Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024


Chicago Style

Modh, Jinal M, Amita R Kubavat, and Anil P Singh. "Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024


MLA (The Modern Language Association) Style

Modh, Jinal M, Amita R Kubavat, and Anil P Singh. "Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study." National Journal of Physiology, Pharmacy and Pharmacology 14.10 (2024), 2266-2271. Print. doi:10.5455/njppp.2024.13.072742024202082024


APA (American Psychological Association) Style

Modh, J. M., Kubavat, . A. R. & Singh, . A. P. (2024) Efficacy and safety of deferasirox in thalassemia major patients after repeated blood transfusion: A single-center study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2266-2271. doi:10.5455/njppp.2024.13.072742024202082024




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