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Original Research
Online Published: 11 Jul 2024
 


Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study

Chiranjeevi Uday Kumar, Anandarupa Tripathy, Vijay K Yalamanchili, Prabhakar Reddy C.


Abstract
Background: Neonatal sepsis is a critical health issue worldwide, with high morbidity and mortality rates, especially in developing countries. Effective management of neonatal sepsis includes timely administration of appropriate antibiotics based on antimicrobial susceptibility patterns.

Aims and Objectives: This cross-sectional study aimed to investigate the choice of empiric and definitive antibiotics in neonatal septicemia, assess bacterial susceptibility patterns, and correlation with clinical outcomes, and highlight the importance of antimicrobial stewardship.

Materials and Methods: The study was conducted at a tertiary care center and enrolled neonates diagnosed with septicemia over 2 months. Blood cultures were obtained, and antibiotics were initiated empirically based on local guidelines. Definitive antibiotics were started after culture sensitivity reports and compared with empiric treatment for clinical outcomes and bacteriological profiles were analyzed with appropriate statistical methods.

Results: In this study, Piperacillin-Tazobactam and Amikacin were used as empiric treatment in all cases. Meropenem showed high sensitivity in definitive treatment post-culture. No significant difference between empiric and definitive treatment groups was observed in clinical outcomes.

Conclusion: This study found no significant difference in clinical outcomes between empiric and definitive antibiotic regimens for neonatal sepsis. However, high meropenem susceptibility suggests the potential for more targeted therapy. Regularly updating local antibiogram, data remain crucial to optimize empiric treatment and combat resistance in this vulnerable population.

Key words: Neonatal Sepsis; Empiric Treatment; Klebsiella; Meropenem


 
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How to Cite this Article
Pubmed Style

Kumar CU, Tripathy A, Yalamanchili VK, C PR. Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2024; 14(8): 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024

Web Style

Kumar CU, Tripathy A, Yalamanchili VK, C PR. Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. https://www.njppp.com/?mno=207734 [Access: September 12, 2024]. doi:10.5455/njppp.2024.14.07272202405072024

AMA (American Medical Association) Style

Kumar CU, Tripathy A, Yalamanchili VK, C PR. Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2024; 14(8): 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024


Vancouver/ICMJE Style

Kumar CU, Tripathy A, Yalamanchili VK, C PR. Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2024), [cited September 12, 2024]; 14(8): 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024


Harvard Style

Kumar, C. U., Tripathy, . A., Yalamanchili, . V. K. & C, . P. R. (2024) Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. Natl J Physiol Pharm Pharmacol, 14 (8), 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024


Turabian Style

Kumar, Chiranjeevi Uday, Anandarupa Tripathy, Vijay K Yalamanchili, and Prabhakar Reddy C. 2024. Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (8), 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024


Chicago Style

Kumar, Chiranjeevi Uday, Anandarupa Tripathy, Vijay K Yalamanchili, and Prabhakar Reddy C. "Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024


MLA (The Modern Language Association) Style

Kumar, Chiranjeevi Uday, Anandarupa Tripathy, Vijay K Yalamanchili, and Prabhakar Reddy C. "Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 14.8 (2024), 1702-1707. Print. doi:10.5455/njppp.2024.14.07272202405072024


APA (American Psychological Association) Style

Kumar, C. U., Tripathy, . A., Yalamanchili, . V. K. & C, . P. R. (2024) Evaluating the impact of culture-guided antibiotic therapy on clinical outcomes in neonatal septicemia: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (8), 1702-1707. doi:10.5455/njppp.2024.14.07272202405072024




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