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Original Research
Online Published: 12 Jul 2024
 


Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice

Hemalatha A, Latha Priya A, Vijay Babu K.


Abstract
Background: Antiepileptic activity was observed with an antiarrhythmic beta-blocker. In this context, the present study was designed to demonstrate the effects of nebivolol on the epilepsy experimental model.

Aim and Objective: This study aimed to compare the anticonvulsant activity of sodium valproate and nebivolol on pentylenetetrazole-induced seizure model of Swiss albino mice.

Materials and Methods: Twenty-four male Swiss strain albino mice of either sex were used in this study. The efficacy of nebivolol and sodium valproate was evaluated against pentylenetetrazole-induced seizure model of Swiss albino mice.

Results: The latency of seizure and duration of seizure in rats of Group 1 and Group 2 was significantly higher compared with Group 3 control rats. There was no significant difference in the latency period of Group 1 and Group 2 rats.

Conclusion: Nebivolol exhibited anti-epileptic activity against the pentylenetetrazole mice model.

Key words: Beta Blockers; Epilepsy; Pentylenetetrazole; Anticonvulsant Activity; Nebivolol


 
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Pubmed Style

A H, A LP, K VB. Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2024; 14(8): 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024

Web Style

A H, A LP, K VB. Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. https://www.njppp.com/?mno=207651 [Access: September 13, 2024]. doi:10.5455/njppp.2024.14.06265202404072024

AMA (American Medical Association) Style

A H, A LP, K VB. Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2024; 14(8): 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024


Vancouver/ICMJE Style

A H, A LP, K VB. Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. Natl J Physiol Pharm Pharmacol. (2024), [cited September 13, 2024]; 14(8): 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024


Harvard Style

A, H., A, . L. P. & K, . V. B. (2024) Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. Natl J Physiol Pharm Pharmacol, 14 (8), 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024


Turabian Style

A, Hemalatha, Latha Priya A, and Vijay Babu K. 2024. Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 14 (8), 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024


Chicago Style

A, Hemalatha, Latha Priya A, and Vijay Babu K. "Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024


MLA (The Modern Language Association) Style

A, Hemalatha, Latha Priya A, and Vijay Babu K. "Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 14.8 (2024), 1728-1731. Print. doi:10.5455/njppp.2024.14.06265202404072024


APA (American Psychological Association) Style

A, H., A, . L. P. & K, . V. B. (2024) Comparison of anticonvulsant activity of nebivolol with sodium valproate in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 14 (8), 1728-1731. doi:10.5455/njppp.2024.14.06265202404072024




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