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Original Research
Online Published: 04 Jul 2024
 


Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study

Sushmma Kalla, Mahammad Jubair S, Monica N, Syed Atiq-Ur Rahman, Kandula Chaitanya, Nabita Subhani Misbah, Aqheel Ahmed, Akhila Prathi.


Abstract
Background: Allergic conjunctivitis, causing eye inflammation and redness, requires effective treatment with alcaftadine 0.25% and olopatadine 0.2% eye drops.

Aims and Objectives: The aim of the study was to compare the efficacy and safety of alcaftadine and olopatadine ophthalmic medications in mild-to-moderate allergic conjunctivitis.

Materials and Methods: A prospective, open-label, comparative study of 60 patients randomized into two study groups of 30 patients each. Each group was assigned to receive either olopatadine or alcaftadine ophthalmic solutions. Patients were followed through at regular intervals with a reduction of signs and symptoms documented using total ocular symptom scoring (TOSS) and hyperemia scale systems.

Results: Baseline (1st visit) mean TOSS scores for the alcaftadine group and olopatadine groups were (6.12±1.92) and (6.32±1.80), respectively, as compared to the corresponding TOSS scores on 14th Day (4th visit) which were (0.5±0.11) and (0.9±0.40), respectively. The resolution of conjunctival symptoms in the alcaftadine group was significantly profoundly as comparison to olopatadine group (P = 0.004). Baseline (1st visit) mean hyperemia scores for alcaftadine group and olopatadine groups were (2.1±1.71) and (2.2±1.52), respectively, as comparison to the corresponding hyperemia scores on 14th day (4th visit) which were (0.08±0.01) and (0.6±0.32), respectively. The resolution of hyperemia symptoms in the alcaftadine group was significantly profound as compared to the olopatadine group (P = 0.002).

Conclusion: Two topical medications utilized in the study were effective and safe for the therapy of allergic conjunctivitis. However, alcaftadine appears to surpass olopatadine in alleviating the symptoms of allergic conjunctivitis while having a lower side effect profile.

Key words: Alcaftadine; Olopatadine; Hyperemia Scale; Allergic Conjunctivitis; Total Ocular Symptom Score


 
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How to Cite this Article
Pubmed Style

Kalla S, S MJ, N M, Rahman SA, Chaitanya K, Misbah NS, Ahmed A, Prathi A. Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024

Web Style

Kalla S, S MJ, N M, Rahman SA, Chaitanya K, Misbah NS, Ahmed A, Prathi A. Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. https://www.njppp.com/?mno=204742 [Access: October 03, 2024]. doi:10.5455/njppp.2024.14.06260202428062024

AMA (American Medical Association) Style

Kalla S, S MJ, N M, Rahman SA, Chaitanya K, Misbah NS, Ahmed A, Prathi A. Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. Natl J Physiol Pharm Pharmacol. 2024; 14(10): 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024


Vancouver/ICMJE Style

Kalla S, S MJ, N M, Rahman SA, Chaitanya K, Misbah NS, Ahmed A, Prathi A. Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. Natl J Physiol Pharm Pharmacol. (2024), [cited October 03, 2024]; 14(10): 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024


Harvard Style

Kalla, S., S, . M. J., N, . M., Rahman, . S. A., Chaitanya, . K., Misbah, . N. S., Ahmed, . A. & Prathi, . A. (2024) Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. Natl J Physiol Pharm Pharmacol, 14 (10), 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024


Turabian Style

Kalla, Sushmma, Mahammad Jubair S, Monica N, Syed Atiq-Ur Rahman, Kandula Chaitanya, Nabita Subhani Misbah, Aqheel Ahmed, and Akhila Prathi. 2024. Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024


Chicago Style

Kalla, Sushmma, Mahammad Jubair S, Monica N, Syed Atiq-Ur Rahman, Kandula Chaitanya, Nabita Subhani Misbah, Aqheel Ahmed, and Akhila Prathi. "Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024


MLA (The Modern Language Association) Style

Kalla, Sushmma, Mahammad Jubair S, Monica N, Syed Atiq-Ur Rahman, Kandula Chaitanya, Nabita Subhani Misbah, Aqheel Ahmed, and Akhila Prathi. "Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study." National Journal of Physiology, Pharmacy and Pharmacology 14.10 (2024), 2171-2176. Print. doi:10.5455/njppp.2024.14.06260202428062024


APA (American Psychological Association) Style

Kalla, S., S, . M. J., N, . M., Rahman, . S. A., Chaitanya, . K., Misbah, . N. S., Ahmed, . A. & Prathi, . A. (2024) Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (10), 2171-2176. doi:10.5455/njppp.2024.14.06260202428062024




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