E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 16 Mar 2024
 


Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study

Mirshad P V, Jobin Louis, Yousef Hisham, Muhamed Sajid, Jeeja M C, Mumtaz P.


Abstract
Background: Surgical site infections (SSIs) present a formidable challenge in contemporary healthcare, impacting patient well-being and contributing to escalating healthcare costs. The judicious utilization of antimicrobial agents is paramount in effectively combating SSIs. This study, conducted at a Tertiary Care Teaching Hospital in Kerala, seeks to unravel the intricate patterns of antimicrobial agent usage within the General Surgery Department over 10 months.

Aims and Objectives: The primary aim is to thoroughly examine antimicrobial agent patterns within the General Surgery Department, focusing specifically on patients undergoing surgical procedures. The study aims to assess the appropriateness of antimicrobial agent usage, encompassing the choice for prophylactic purposes, timing of pre-operative dosing, the occurrence of intraoperative dosing, and the selection appropriateness for post-operative prophylaxis.

Materials and Methods: Crafted for robust analysis, the study included 150 cases, implementing specific inclusion and exclusion criteria to ensure data quality. The emphasis was placed on patients undergoing surgical procedures, focusing on prophylactic antimicrobial use. Data collection involved meticulously evaluating appropriateness across critical parameters, including the choice of prophylactic antimicrobial agent, pre-operative dosing timing, intraoperative dosing, and selection appropriateness for post-operative prophylaxis.

Results: Analysis of 150 cases provided valuable insights into the age and gender distribution, predominantly within the 41–60 age groups. Prevalent surgical procedures, such as hernia and appendicitis, underscored the necessity for tailored antimicrobial protocols. Cephalosporins emerged as the dominant class, raising concerns about potential overuse and resistance. Pre-exposure prophylactic antibiotics, predominantly cephalosporins, were administered in 88 cases. Post-exposure prophylaxis mirrored this trend, necessitating a critical evaluation of antibiotic selection and duration. Detailed analysis of cephalosporin pre- and post-exposure prophylaxis identified prevalent choices such as Cefotaxime and Cefoperazone + Sulbactam, emphasizing the importance of scrutinizing cephalosporin selection.

Conclusion: This study furnishes valuable insights into the appropriateness of antimicrobial agent usage for preventing SSIs, serving as a model for analogous healthcare settings. It underscores the significance of local antibiotic stewardship, guideline adherence, and the ongoing commitment to optimizing prophylactic antimicrobial usage for ensuring patient safety and advancing healthcare quality amidst evolving challenges.

Key words: Surgical Site Infections; Antimicrobial Stewardship; Prophylactic Antibiotic Usage; Cephalosporin Resistance; Tertiary Care Teaching Hospital; Antibiotic Appropriateness


 
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How to Cite this Article
Pubmed Style

V MP, Louis J, Hisham Y, Sajid M, C JM, P M. Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. Natl J Physiol Pharm Pharmacol. 2024; 14(4): 705-709. doi:10.5455/njppp.2024.14.020950202406032024


Web Style

V MP, Louis J, Hisham Y, Sajid M, C JM, P M. Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. https://www.njppp.com/?mno=192519 [Access: November 02, 2024]. doi:10.5455/njppp.2024.14.020950202406032024


AMA (American Medical Association) Style

V MP, Louis J, Hisham Y, Sajid M, C JM, P M. Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. Natl J Physiol Pharm Pharmacol. 2024; 14(4): 705-709. doi:10.5455/njppp.2024.14.020950202406032024



Vancouver/ICMJE Style

V MP, Louis J, Hisham Y, Sajid M, C JM, P M. Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. Natl J Physiol Pharm Pharmacol. (2024), [cited November 02, 2024]; 14(4): 705-709. doi:10.5455/njppp.2024.14.020950202406032024



Harvard Style

V, M. P., Louis, . J., Hisham, . Y., Sajid, . M., C, . J. M. & P, . M. (2024) Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. Natl J Physiol Pharm Pharmacol, 14 (4), 705-709. doi:10.5455/njppp.2024.14.020950202406032024



Turabian Style

V, Mirshad P, Jobin Louis, Yousef Hisham, Muhamed Sajid, Jeeja M C, and Mumtaz P. 2024. Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (4), 705-709. doi:10.5455/njppp.2024.14.020950202406032024



Chicago Style

V, Mirshad P, Jobin Louis, Yousef Hisham, Muhamed Sajid, Jeeja M C, and Mumtaz P. "Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 705-709. doi:10.5455/njppp.2024.14.020950202406032024



MLA (The Modern Language Association) Style

V, Mirshad P, Jobin Louis, Yousef Hisham, Muhamed Sajid, Jeeja M C, and Mumtaz P. "Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study." National Journal of Physiology, Pharmacy and Pharmacology 14.4 (2024), 705-709. Print. doi:10.5455/njppp.2024.14.020950202406032024



APA (American Psychological Association) Style

V, M. P., Louis, . J., Hisham, . Y., Sajid, . M., C, . J. M. & P, . M. (2024) Antimicrobial agent usage patterns and their role in preventing surgical site infections at a tertiary care teaching hospital: A comprehensive study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (4), 705-709. doi:10.5455/njppp.2024.14.020950202406032024