A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital

Kiran M; Nagabushan H; Rekha M C

doi:10.5455/njppp.2024.14.01043202410022024

2024, Vol: 14, Issue: 4

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Online Publishing Date:
21 / 02 / 2024

Natl J Physiol Pharm Pharmacol. 2024; 14(8):

doi: 10.5455/njppp.2024.14.01043202410022024

A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital

Kiran M, Nagabushan H, Rekha M C.

Abstract
Background: Antitubercular drugs are commonly associated with drug-induced liver injury (DILI), which can present as asymptomatic alterations in liver function test (LFT) to symptomatic hepatic injury and failure. Regular and frequent monitoring of LFT during intensive phase of therapy helps to identify early DILI and its complication.

Aims and Objectives: The main objective was to evaluate the effects of antitubercular drugs on liver functions by early monitoring.

Materials and Methods: A prospective observational study was conducted for 1 year among 97 newly diagnosed tuberculosis patients in tertiary care hospital. LFT was performed during baseline, at the end of 2nd week, and at end of intensive phase of treatment. Diagnosis of liver injury was based on DILI criteria and assessment of the clinical pattern of liver damage was done using “R value”.

Results: Among 97 patients, 16 had experienced DILI and incidence was higher during the first visit. Aspartate aminotransferase (AST) and alanine aminotransferase were significantly altered during the first visit while AST and total bilirubin during the second visit. The number of parameters deranged was higher at the end of intensive phase than during the end of 2nd week. Cholestatic pattern (81.25 %) of liver injury was the most common type as per “R value”. According to DILI network severity index, the majority were categorized as “moderately-severe” and “moderate” during the first and second follow-up, respectively.

Conclusion: The incidence of antitubercular drugs-induced liver injury was higher during the initial 2 weeks of treatment, but the derangement was more evident at the end of the intensive phase. Frequent and regular monitoring during the initial phase of treatment helps to detect early DILI which prevents the impending liver failure.

Key words: Antitubercular Treatment; Drug Induced Liver Injury; Hepatotoxicity; Liver Function Tests; R-value

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Pubmed Style

M K, H N, C RM. A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. Natl J Physiol Pharm Pharmacol. Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

Web Style

M K, H N, C RM. A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. https://www.njppp.com/?mno=188263 [Access: March 14, 2024]. doi:10.5455/njppp.2024.14.01043202410022024

AMA (American Medical Association) Style

M K, H N, C RM. A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. Natl J Physiol Pharm Pharmacol. Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

Vancouver/ICMJE Style

M K, H N, C RM. A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. Natl J Physiol Pharm Pharmacol, [cited March 14, 2024]; Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

Harvard Style

M, K., H, . N. & C, . R. M. (2024) A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. Natl J Physiol Pharm Pharmacol, Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

Turabian Style

M, Kiran, Nagabushan H, and Rekha M C. 2024. A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

Chicago Style

M, Kiran, Nagabushan H, and Rekha M C. "A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

M, K., H, . N. & C, . R. M. (2024) A study of the effect of antitubercular drugs on liver functions in newly diagnosed cases of tuberculosis during intensive phase of therapy in tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 21 Feb, 2024. doi:10.5455/njppp.2024.14.01043202410022024

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