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Online Published: 30 Jan 2024
 


Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats

Mahesh Basanagauda Mudhol, Surendra Kumar Gondi, Reddyprasad C.


Abstract
Background: Thiophene, also known as thiofuran, is a heterocyclic molecule represented by the chemical formula C4H4S.

Aim and Objectives: The aim of this study was to evaluate the anti-inflammatory activity of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound in Wistar rats by acute carrageenan-induced paw edema and chronic cotton pellet-induced granuloma methods.

Materials and Methods: This study consists of two stages: An acute inflammation study using carrageenan-induced paw edema in rats, which involves four groups of rats, and a chronic inflammation study using cotton pellet-induced granuloma, which involves three groups of rats. Mean paw edema volume and percentage of inhibition were measured in acute stage. The mean weight of the pellets in each group was determined during the chronic stage.

Results: There was increase in the mean paw volume at 3 h and a slow decrease at 6 h and 24 h in control group to thiophene derivative-20 mg/kg/p.o from 0 h to 24 h. The mean difference from control and at 3 h, 6 h, and 24 h showed that mean difference was slowly decreased and it was statistically significant. The mean dry granuloma weight in control group, i.e., 10% tween 80 treated group was 146.6 ± 4.38. The mean dry granuloma weight in standard group, i.e., indomethacin 3 mg/kg treated group was 87.7 ± 3.41. The mean dry granuloma weight in substituted thiophene 10 mg/kg group was 101.91 ± 3.76.

Conclusions: The newly synthesized substituted (fused) thiophene compound demonstrated inhibition of inflammation in both acute inflammation induced by carrageenan-induced paw edema and chronic inflammation induced by cotton pellet-induced granuloma in Wistar rats. The compound’s anti-inflammatory effects were comparable to those of the standard drug indomethacin, with a dosage of 10 mg/kg in the acute model and 3 mg/kg in the chronic inflammation model. This concludes that the test compound has anti-inflammatory activity.

Key words: Thiophene Compound; Acute Carrageenan Induced Paw Edema; Chronic Cotton Pellet Induced Granuloma; Wistar Rats


 
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How to Cite this Article
Pubmed Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 302-306. doi:10.5455/njppp.2024.14.01017202416012024

Web Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. https://www.njppp.com/?mno=184700 [Access: September 12, 2024]. doi:10.5455/njppp.2024.14.01017202416012024

AMA (American Medical Association) Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 302-306. doi:10.5455/njppp.2024.14.01017202416012024


Vancouver/ICMJE Style

Mudhol MB, Gondi SK, C R. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol. (2024), [cited September 12, 2024]; 14(2): 302-306. doi:10.5455/njppp.2024.14.01017202416012024


Harvard Style

Mudhol, M. B., Gondi, . S. K. & C, . R. (2024) Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. Natl J Physiol Pharm Pharmacol, 14 (2), 302-306. doi:10.5455/njppp.2024.14.01017202416012024


Turabian Style

Mudhol, Mahesh Basanagauda, Surendra Kumar Gondi, and Reddyprasad C. 2024. Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 302-306. doi:10.5455/njppp.2024.14.01017202416012024


Chicago Style

Mudhol, Mahesh Basanagauda, Surendra Kumar Gondi, and Reddyprasad C. "Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 302-306. doi:10.5455/njppp.2024.14.01017202416012024


MLA (The Modern Language Association) Style

Mudhol, Mahesh Basanagauda, Surendra Kumar Gondi, and Reddyprasad C. "Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats." National Journal of Physiology, Pharmacy and Pharmacology 14.2 (2024), 302-306. Print. doi:10.5455/njppp.2024.14.01017202416012024


APA (American Psychological Association) Style

Mudhol, M. B., Gondi, . S. K. & C, . R. (2024) Pharmacological evaluation of 2-(2-hydroxy phenylimino)-N-(2-chlorophenyl)-5-isopropyl-4-methylthiophene-3-carboxamide compound for anti-inflammatory activity in rats. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 302-306. doi:10.5455/njppp.2024.14.01017202416012024




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