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Original Research
Online Published: 01 Mar 2024
 


Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha

Sanjay Kumar Mahapatra, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, Mousumee Panigrahi.


Abstract
Background: Metastatic castration sensitive prostate cancer (mCSPC) has different modalities of management. However, with the arrival of abiraterone acetate (AA), the management of this condition has changed to a greater extent.

Aims and Objectives: As a new molecule its effectiveness and safety are being evaluated in our patient population as a prospective observational study for 18 months.

Materials and Methods: This study included 50 patients who were treated with AA according to the treating physician. The overall survival observed at 18 months was 88%.

Results: There was a significant decrease in mean serum prostate-specific antigen level with treatment. About 60% of patients were completely adhered to the treatment. About 94% of patients experienced some form of adverse event and 10% of patients died in this study. Though the molecule has adverse effects, the overall survival of the patients has increased.

Conclusion: The efficacy of AA was observed consistent with the time in mCSPC patients with manageable adverse events.

Key words: Abiraterone; Metastatic Castration Sensitive Prostate Cancer; Serum Prostate-Specific Antigen Level


 
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How to Cite this Article
Pubmed Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol. 2024; 14(8): 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024

Web Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. https://www.njppp.com/?mno=177870 [Access: September 12, 2024]. doi:10.5455/njppp.2024.14.11548202318022024

AMA (American Medical Association) Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol. 2024; 14(8): 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024


Vancouver/ICMJE Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol. (2024), [cited September 12, 2024]; 14(8): 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024


Harvard Style

Mahapatra, S. K., Pradhan, . S., Dash, . R. R., Rath, . B., Goutam, . S. & Panigrahi, . M. (2024) Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol, 14 (8), 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024


Turabian Style

Mahapatra, Sanjay Kumar, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, and Mousumee Panigrahi. 2024. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. National Journal of Physiology, Pharmacy and Pharmacology, 14 (8), 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024


Chicago Style

Mahapatra, Sanjay Kumar, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, and Mousumee Panigrahi. "Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024


MLA (The Modern Language Association) Style

Mahapatra, Sanjay Kumar, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, and Mousumee Panigrahi. "Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha." National Journal of Physiology, Pharmacy and Pharmacology 14.8 (2024), 1576-1581. Print. doi:10.5455/njppp.2024.14.11548202318022024


APA (American Psychological Association) Style

Mahapatra, S. K., Pradhan, . S., Dash, . R. R., Rath, . B., Goutam, . S. & Panigrahi, . M. (2024) Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. National Journal of Physiology, Pharmacy and Pharmacology, 14 (8), 1576-1581. doi:10.5455/njppp.2024.14.11548202318022024




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