Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha

Sanjay Kumar Mahapatra; Subhrasmita Pradhan; Rinu Rani Dash; Bhabagrahi Rath; Siddhartha Goutam; Mousumee Panigrahi

doi:10.5455/njppp.2024.14.11548202318022024

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Online Publishing Date:
01 / 03 / 2024

Natl J Physiol Pharm Pharmacol. 2024; 14(8):

doi: 10.5455/njppp.2024.14.11548202318022024

Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha

Sanjay Kumar Mahapatra, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, Mousumee Panigrahi.

Abstract
Background: Metastatic castration sensitive prostate cancer (mCSPC) has different modalities of management. However, with the arrival of abiraterone acetate (AA), the management of this condition has changed to a greater extent.

Aims and Objectives: As a new molecule its effectiveness and safety are being evaluated in our patient population as a prospective observational study for 18 months.

Materials and Methods: This study included 50 patients who were treated with AA according to the treating physician. The overall survival observed at 18 months was 88%.

Results: There was a significant decrease in mean serum prostate-specific antigen level with treatment. About 60% of patients were completely adhered to the treatment. About 94% of patients experienced some form of adverse event and 10% of patients died in this study. Though the molecule has adverse effects, the overall survival of the patients has increased.

Conclusion: The efficacy of AA was observed consistent with the time in mCSPC patients with manageable adverse events.

Key words: Abiraterone; Metastatic Castration Sensitive Prostate Cancer; Serum Prostate-Specific Antigen Level

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How to Cite this Article

Pubmed Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol. Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

Web Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. https://www.njppp.com/?mno=177870 [Access: March 14, 2024]. doi:10.5455/njppp.2024.14.11548202318022024

AMA (American Medical Association) Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol. Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

Vancouver/ICMJE Style

Mahapatra SK, Pradhan S, Dash RR, Rath B, Goutam S, Panigrahi M. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol, [cited March 14, 2024]; Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

Harvard Style

Mahapatra, S. K., Pradhan, . S., Dash, . R. R., Rath, . B., Goutam, . S. & Panigrahi, . M. (2024) Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. Natl J Physiol Pharm Pharmacol, Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

Turabian Style

Mahapatra, Sanjay Kumar, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, and Mousumee Panigrahi. 2024. Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

Chicago Style

Mahapatra, Sanjay Kumar, Subhrasmita Pradhan, Rinu Rani Dash, Bhabagrahi Rath, Siddhartha Goutam, and Mousumee Panigrahi. "Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha." National Journal of Physiology, Pharmacy and Pharmacology Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Mahapatra, S. K., Pradhan, . S., Dash, . R. R., Rath, . B., Goutam, . S. & Panigrahi, . M. (2024) Effectiveness and safety of abiraterone acetate in metastatic castration-sensitive prostate cancer patients of Western Odisha. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 01 Mar, 2024. doi:10.5455/njppp.2024.14.11548202318022024

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