Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle

Yogita D Sulaxane; Sharad G Patel

doi:10.5455/njppp.2015.5.3001201536

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Original Research
Online Published: 16 Sep 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(4): 328-332

doi: 10.5455/njppp.2015.5.3001201536

Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle

Yogita D Sulaxane, Sharad G Patel.

Cited By:6

Abstract
Background: The physiologic mechanisms whereby the human endometrium maintains hemostasis during endovascular trophoblast invasion, yet permits menstrual hemorrhage, are unknown.

Aims and Objective: To find out whether hemostatic responses alter during various phases of normal menstruation.

Materials and Methods: In this study height, weight, body mass index, pulse, and blood pressure were measured in 60 female volunteers having normal, regular menstrual cycle. Bleeding and clotting time were measured during three phases of single menstrual cycle: menstrual, follicular, and luteal. One-way analysis of variance test with Bonferroni correction was used to find out statistical significance.

Results: This study shows mean bleeding time at follicular phase was significantly (P < 0.05) less as compared to that at menstrual and luteal phases. Mean clotting time at follicular phase was comparatively less than that at menstrual and luteal phases, but the difference was not significant (P > 0.05).

Conclusion: Our observations indicate that primary and secondary hemostatic mechanism activities are at their high in the follicular phase than in the luteal and menstrual phases.

Key words: Menstrual Cycle; Bleeding Time; Clotting Time; Hemostasis

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Pubmed Style

Sulaxane YD, Patel SG. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 328-332. doi:10.5455/njppp.2015.5.3001201536

Web Style

Sulaxane YD, Patel SG. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. https://www.njppp.com/?mno=175878 [Access: May 06, 2025]. doi:10.5455/njppp.2015.5.3001201536

AMA (American Medical Association) Style

Sulaxane YD, Patel SG. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 328-332. doi:10.5455/njppp.2015.5.3001201536

Vancouver/ICMJE Style

Sulaxane YD, Patel SG. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol. (2015), [cited May 06, 2025]; 5(4): 328-332. doi:10.5455/njppp.2015.5.3001201536

Harvard Style

Sulaxane, Y. D. & Patel, . S. G. (2015) Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol, 5 (4), 328-332. doi:10.5455/njppp.2015.5.3001201536

Turabian Style

Sulaxane, Yogita D, and Sharad G Patel. 2015. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 328-332. doi:10.5455/njppp.2015.5.3001201536

Chicago Style

Sulaxane, Yogita D, and Sharad G Patel. "Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 328-332. doi:10.5455/njppp.2015.5.3001201536

MLA (The Modern Language Association) Style

Sulaxane, Yogita D, and Sharad G Patel. "Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle." National Journal of Physiology, Pharmacy and Pharmacology 5.4 (2015), 328-332. Print. doi:10.5455/njppp.2015.5.3001201536

APA (American Psychological Association) Style

Sulaxane, Y. D. & Patel, . S. G. (2015) Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 328-332. doi:10.5455/njppp.2015.5.3001201536

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