Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease

Sandhya Metta; Prasad D K V; Jayabalakrishnan S; Syamala Devi M; Joya Rani D

doi:10.5455/njppp.2023.13.10484202319102023

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Online Publishing Date:
02 / 11 / 2023

Natl J Physiol Pharm Pharmacol. 2024; 14(6):

doi: 10.5455/njppp.2023.13.10484202319102023

Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease

Sandhya Metta, Prasad D K V, Jayabalakrishnan S, Syamala Devi M, Joya Rani D.

Abstract
Background: Endothelial nitric oxide synthase (eNOS) enzyme plays a key role in maintaining optimal cardiovascular health. Furthermore, the literature review suggests the prominence eNOS gene polymorphisms in pathophysiology of ischemic heart disease (IHD).

Aim and Objectives: The aim of this study was to evaluate the association of eNOS gene intron 4a/b polymorphism with IHD in smokers.

Materials and Methods: Two hundred male patients presenting with IHD and 100 and 27 age-matched healthy males from the same demographic area were recruited for the study. Based on the history of smoking habit (≥20 pack years of smoking), the subjects were further categorized into non-smokers and smokers. All the subjects were analyzed for the eNOS gene 4a/b polymorphism and other relevant parameters.

Results: While studying the association of “aa” genotype with smoking in the patient group as well as in control group, there was no significant association observed between smoking behavior and genotype frequencies (for aa vs. ab+bb, odds ratio [OR] 1.5682, 95% confidence interval [CI] 0.6119–4.0191, P = 0.3457) in patient smokers versus patient non-smokers, OR 0.59, 95% CI 0.1349–2.581, P = 0.479 in control smokers versus control non-smokers.

Conclusion: Although genotype frequencies for eNOS 4 b/b, eNOS 4 a/b and eNOS 4 a/a and “a” allele frequency differed between IHD patients and controls, it was not statistically significant indicating “a” allele of eNOS intron 4 a/b variable number of tandem repeat polymorphism was not an independent predictor of IHD.

Key words: Endothelial Nitric Oxide Synthase Gene; Polymorphism; Smoking; Ischemic Heart Disease

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How to Cite this Article

Pubmed Style

Metta S, V PDK, S J, M SD, D JR. Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. Natl J Physiol Pharm Pharmacol. Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

Web Style

Metta S, V PDK, S J, M SD, D JR. Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. https://www.njppp.com/?mno=172161 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.10484202319102023

AMA (American Medical Association) Style

Metta S, V PDK, S J, M SD, D JR. Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. Natl J Physiol Pharm Pharmacol. Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

Vancouver/ICMJE Style

Metta S, V PDK, S J, M SD, D JR. Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. Natl J Physiol Pharm Pharmacol, [cited March 14, 2024]; Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

Harvard Style

Metta, S., V, . P. D. K., S, . J., M, . S. D. & D, . J. R. (2024) Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. Natl J Physiol Pharm Pharmacol, Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

Turabian Style

Metta, Sandhya, Prasad D K V, Jayabalakrishnan S, Syamala Devi M, and Joya Rani D. 2024. Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

Chicago Style

Metta, Sandhya, Prasad D K V, Jayabalakrishnan S, Syamala Devi M, and Joya Rani D. "Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease." National Journal of Physiology, Pharmacy and Pharmacology Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Metta, S., V, . P. D. K., S, . J., M, . S. D. & D, . J. R. (2024) Study of association of endothelial nitric oxide synthase gene intron 4a/b polymorphism in smokers with ischemic heart disease. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 02 Nov, 2023. doi:10.5455/njppp.2023.13.10484202319102023

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