Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population

Irfan Ahmad Khan; Dibyadeb Ghosh; Masuram Bharath Kumar

doi:10.5455/njppp.2023.13.09429202310092023

2024, Vol: 14, Issue: 4

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Online Publishing Date:
22 / 09 / 2023

Natl J Physiol Pharm Pharmacol. 2024; 14(4):

doi: 10.5455/njppp.2023.13.09429202310092023

Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population

Irfan Ahmad Khan, Dibyadeb Ghosh, Masuram Bharath Kumar.

Abstract
Background: Vitamin D deficiency has recently been shown to play a role in insulin resistance and derangement of insulin secretion, which in turn may affect type 2 diabetes adversely.

Aims and Objectives: The objective of this study was to investigate the association between vitamin D deficiency and insulin resistance in type 2 diabetic patients.

Materials and Methods: A cross-sectional observational study was conducted on 100 type 2 diabetic patients aged 30–75 years, with both genders (60 male and 40 female). To analyze, the relationship between vitamin D and glycemic parameters, a Pearson correlation was performed.

Results: In this present study, we found a negative significant correlation between vitamin D and fasting insulin r = −0.33 (P < 0.001) it was also true for homeostatic model assessment-insulin resistance and fasting plasma glucose r = −0.42, r = −0.43 (P < 0.001), respectively. Furthermore, vitamin D was positively correlated QUICKI model in type 2 diabetes mellitus (T2DM).

Conclusion: From the findings, we can conclude that vitamin D deficiency has an important role in insulin resistance hence, vitamin D supplementation could improve glycemic control in T2DM.

Key words: Type 2 Diabetes mellitus; Homeostatic Model Assessment-Insulin Resistance; QUICKI; Fasting Insulin; 25(OH)D

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Pubmed Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol. Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

Web Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. https://www.njppp.com/?mno=168480 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.09429202310092023

AMA (American Medical Association) Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol. Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

Vancouver/ICMJE Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol, [cited March 15, 2024]; Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

Harvard Style

Khan, I. A., Ghosh, . D. & Kumar, . M. B. (2024) Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol, Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

Turabian Style

Khan, Irfan Ahmad, Dibyadeb Ghosh, and Masuram Bharath Kumar. 2024. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

Chicago Style

Khan, Irfan Ahmad, Dibyadeb Ghosh, and Masuram Bharath Kumar. "Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population." National Journal of Physiology, Pharmacy and Pharmacology Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Khan, I. A., Ghosh, . D. & Kumar, . M. B. (2024) Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 22 Sep, 2023. doi:10.5455/njppp.2023.13.09429202310092023

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