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Online Published: 22 Sep 2023
 


Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population

Irfan Ahmad Khan, Dibyadeb Ghosh, Masuram Bharath Kumar.


Abstract
Background: Vitamin D deficiency has recently been shown to play a role in insulin resistance and derangement of insulin secretion, which in turn may affect type 2 diabetes adversely.

Aims and Objectives: The objective of this study was to investigate the association between vitamin D deficiency and insulin resistance in type 2 diabetic patients.

Materials and Methods: A cross-sectional observational study was conducted on 100 type 2 diabetic patients aged 30–75 years, with both genders (60 male and 40 female). To analyze, the relationship between vitamin D and glycemic parameters, a Pearson correlation was performed.

Results: In this present study, we found a negative significant correlation between vitamin D and fasting insulin r = −0.33 (P < 0.001) it was also true for homeostatic model assessment-insulin resistance and fasting plasma glucose r = −0.42, r = −0.43 (P < 0.001), respectively. Furthermore, vitamin D was positively correlated QUICKI model in type 2 diabetes mellitus (T2DM).

Conclusion: From the findings, we can conclude that vitamin D deficiency has an important role in insulin resistance hence, vitamin D supplementation could improve glycemic control in T2DM.

Key words: Type 2 Diabetes mellitus; Homeostatic Model Assessment-Insulin Resistance; QUICKI; Fasting Insulin; 25(OH)D


 
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How to Cite this Article
Pubmed Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol. 2024; 14(4): 642-646. doi:10.5455/njppp.2023.13.09429202310092023

Web Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. https://www.njppp.com/?mno=168480 [Access: April 17, 2025]. doi:10.5455/njppp.2023.13.09429202310092023

AMA (American Medical Association) Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol. 2024; 14(4): 642-646. doi:10.5455/njppp.2023.13.09429202310092023


Vancouver/ICMJE Style

Khan IA, Ghosh D, Kumar MB. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol. (2024), [cited April 17, 2025]; 14(4): 642-646. doi:10.5455/njppp.2023.13.09429202310092023


Harvard Style

Khan, I. A., Ghosh, . D. & Kumar, . M. B. (2024) Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. Natl J Physiol Pharm Pharmacol, 14 (4), 642-646. doi:10.5455/njppp.2023.13.09429202310092023


Turabian Style

Khan, Irfan Ahmad, Dibyadeb Ghosh, and Masuram Bharath Kumar. 2024. Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. National Journal of Physiology, Pharmacy and Pharmacology, 14 (4), 642-646. doi:10.5455/njppp.2023.13.09429202310092023


Chicago Style

Khan, Irfan Ahmad, Dibyadeb Ghosh, and Masuram Bharath Kumar. "Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 642-646. doi:10.5455/njppp.2023.13.09429202310092023


MLA (The Modern Language Association) Style

Khan, Irfan Ahmad, Dibyadeb Ghosh, and Masuram Bharath Kumar. "Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population." National Journal of Physiology, Pharmacy and Pharmacology 14.4 (2024), 642-646. Print. doi:10.5455/njppp.2023.13.09429202310092023


APA (American Psychological Association) Style

Khan, I. A., Ghosh, . D. & Kumar, . M. B. (2024) Association of 25(OH)D deficiency and insulin resistance in type 2 diabetics in semi-urban North Indian population. National Journal of Physiology, Pharmacy and Pharmacology, 14 (4), 642-646. doi:10.5455/njppp.2023.13.09429202310092023


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