Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region

Nilesh B Chavda; Priti P Solanky; Hinal Baria; Ruchi Naik; Komal Bharti

doi:10.5455/njppp.2015.5.0508201428

2024, Vol: 14, Issue: 10

14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form

« Previous Article

Original Research
Online Published: 02 Jul 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(3): 236-242

doi: 10.5455/njppp.2015.5.0508201428

Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik, Komal Bharti.

Cited By:25

Abstract
Background: Drugdrug interactions (DDIs) are very common and responsible for 6%30% of the adverse drug events that will increase healthcare cost and patient outcome. Polypharmacy significantly contributes to DDIs.

Aims and Objective: To assess the DDIs in the outpatients in the medicine department in a tertiary-care hospital.

Materials and Methods: The prescription of patients attending OPD of medicine department were analyzed for demography of patients and potential drugdrug interaction (pDDI). pDDI were checked by freely available drug interaction checker on Internet. pDDI were classified major, moderate, and minor according to severity and, by its mechanism, as pharmacokinetic, pharmacodynamic, or pharmacokinetic + pharmacodynamic. Statistical analysis was done using appropriate statistical software (MS Excel, Epi info, etc.).

Results: Of the 300 patients who attended the medicine OPD during the study period, 253 patients were included in our study. From these, 128 (50.59%) were men and 125 (49.41%) women. Among these 253 patients, 147 (58.27%) patients had at least one pDDI and 106 (41.9%) patients had no pDDIs. The incidence of pDDI per patient was 1.68 ± 2.68 in our study. Average number of drugs prescribed per patient was 4.4 ± 1.48 in our study. A direct correlation was observed between the age of the patients and the number of pDDIs (r = 0.35, P < 0.01), between the age of the patients and the number of the drugs prescribed (r = 0.18, P < 0.01), and between the number of drugs prescribed and the number of pDDIs (r = 0.69, P < 0.01). Among 423 pDDIs, 215 (50.83%) were pharmacodynamic drug interactions, 163 (38.53%) pharmacokinetic, and 45 (10.64%) showed both kinds of mechanisms. Interactions with major severity accounted for seven (1.65%) of the total pDDIs, while those with moderate and minor severity accounted for 321 (75.87%) and 95 (22.46%), respectively.

Conclusions: In our study, we found that most common pDDIs were pharmacodynamic in nature and of moderate severity. The number of pDDI increased with increase in the age of patients and the number of drugs prescribed.

Key words: Potential DrugDrug Interaction (pDDI); Pharmacokinetic Drug Interaction; Pharmacodynamic Drug Interaction; Severity of Drug Interaction

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Nilesh B Chavda Articles by Priti P Solanky Articles by Hinal Baria Articles by Ruchi Naik Articles by Komal Bharti
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 236-242. doi:10.5455/njppp.2015.5.0508201428

Web Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. https://www.njppp.com/?mno=165251 [Access: November 02, 2024]. doi:10.5455/njppp.2015.5.0508201428

AMA (American Medical Association) Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 236-242. doi:10.5455/njppp.2015.5.0508201428

Vancouver/ICMJE Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. Natl J Physiol Pharm Pharmacol. (2015), [cited November 02, 2024]; 5(3): 236-242. doi:10.5455/njppp.2015.5.0508201428

Harvard Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti (2015) Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. Natl J Physiol Pharm Pharmacol, 5 (3), 236-242. doi:10.5455/njppp.2015.5.0508201428

Turabian Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. 2015. Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 236-242. doi:10.5455/njppp.2015.5.0508201428

Chicago Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. "Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 236-242. doi:10.5455/njppp.2015.5.0508201428

MLA (The Modern Language Association) Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti. "Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 236-242. Print. doi:10.5455/njppp.2015.5.0508201428

APA (American Psychological Association) Style

Nilesh B Chavda, Priti P Solanky, Hinal Baria, Ruchi Naik , Komal Bharti (2015) Study of potential drugdrug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 236-242. doi:10.5455/njppp.2015.5.0508201428

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Digital Archiving & Preservation Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article