Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center

Karthikeyan T M; Veenaa N N; Shivapriya R; Arun Kumar; Umamageswari M S

doi:10.5455/njppp.2023.13.08381202316082023

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Original Research
Online Published: 04 Sep 2023

Natl J Physiol Pharm Pharmacol. 2024; 14(3): 473-479

doi: 10.5455/njppp.2023.13.08381202316082023

Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center

Karthikeyan T M, Veenaa N N, Shivapriya R, Arun Kumar, Umamageswari M S.

Abstract
Background: Diabetes mellitus (DM) is a common metabolic disorder leading to microvascular and macrovascular complications. Chronic inflammation accelerates the development of complications associated with DM. Measurement of inflammatory mediators is not practically feasible. Neutrophil–lymphocyte ratio (NLR) serves as a cheap, reliable, and valid marker for assessing inflammatory activity.

Aims and Objectives: (i) To evaluate the correlation of NLR and microalbuminuria in DM patients; (ii) to evaluate the correlation of NLR with HbA1c; and (iii) to evaluate the correlation of platelet count with microalbuminuria.

Materials and Methods: One hundred patients of either sex with DM were evaluated for microalbuminuria, NLR, HbA1c, and platelet count after obtaining institutional human ethics committee clearance. NLR was evaluated for correlation with microalbuminuria and HbA1c. Platelet count was also evaluated for correlation with microalbuminuria.

Results: Mean NLR of male patient was 2.1 and female was 2.33. The mean microalbuminuria level in male patient was 527.03 mcg/mg of creatinine and female was 215.36 mcg/mg of creatinine. There was a moderate degree of correlation of microalbuminuria with increased NLR. The study showed a strong correlation between NLR, microalbuminuria, HbA1c, and platelet count.

Conclusion: NLR has a strong correlation with microalbuminuria and could be used to assess the onset and progression of diabetic nephropathy.

Key words: Neutrophil–lymphocyte Ratio; Microalbuminuria; Diabetes Mellitus; HbA1c

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How to Cite this Article

Pubmed Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol. 2024; 14(3): 473-479. doi:10.5455/njppp.2023.13.08381202316082023

Web Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. https://www.njppp.com/?mno=163438 [Access: March 07, 2025]. doi:10.5455/njppp.2023.13.08381202316082023

AMA (American Medical Association) Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol. 2024; 14(3): 473-479. doi:10.5455/njppp.2023.13.08381202316082023

Vancouver/ICMJE Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol. (2024), [cited March 07, 2025]; 14(3): 473-479. doi:10.5455/njppp.2023.13.08381202316082023

Harvard Style

M, K. T., N, . V. N., R, . S., Kumar, . A. & S, . U. M. (2024) Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol, 14 (3), 473-479. doi:10.5455/njppp.2023.13.08381202316082023

Turabian Style

M, Karthikeyan T, Veenaa N N, Shivapriya R, Arun Kumar, and Umamageswari M S. 2024. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. National Journal of Physiology, Pharmacy and Pharmacology, 14 (3), 473-479. doi:10.5455/njppp.2023.13.08381202316082023

Chicago Style

M, Karthikeyan T, Veenaa N N, Shivapriya R, Arun Kumar, and Umamageswari M S. "Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 473-479. doi:10.5455/njppp.2023.13.08381202316082023

MLA (The Modern Language Association) Style

M, Karthikeyan T, Veenaa N N, Shivapriya R, Arun Kumar, and Umamageswari M S. "Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center." National Journal of Physiology, Pharmacy and Pharmacology 14.3 (2024), 473-479. Print. doi:10.5455/njppp.2023.13.08381202316082023

APA (American Psychological Association) Style

M, K. T., N, . V. N., R, . S., Kumar, . A. & S, . U. M. (2024) Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. National Journal of Physiology, Pharmacy and Pharmacology, 14 (3), 473-479. doi:10.5455/njppp.2023.13.08381202316082023

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