E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district

Latha S, Somashekara S C, Satish Ghatage, Suraj B.

Abstract
Background: Drug resistance tuberculosis (DRTB) is an important concern in India as it accounts, one-fourth of global burden. DRTB regimen is associated with adverse drug reactions (ADRs) accounting for significant mortality, non-adherence, and treatment discontinuation. Hence, the present study emphasis to be vigilant about these ADRs.

Aims and Objectives: The aim of the study was to estimate the incidence, various types, and risk factors associated with adverse reactions in DRTB in Northern Karnataka district.

Materials and Methods: A Prospective observational cohort study was conducted at Nodal DRTB center. All diagnosed and treatment initiated pulmonary DRTB patients during January–March 2021 aged ≥18 years of either sex were included, which constituted 70 patients. A pre-designed case report form was used to collect details like sociodemographic information, past history, personal history, and drug regimen along with their contact information of the DRTB patients.

Results: Of 70 study participants, 64% were males and mean age was 36.7 ± 14.5 years with majority being resistant to rifampicin (52%). Incidence of ADR was 32 (46%) and commonly reported ADR were nausea (30%), gastritis (24%), vomiting (21%), arthralgia (9%), and peripheral neuropathy (9%). Causality assessment was done using “Naranjo algorithm,” majority were probable (79.01%) and as per the modified Hartwig and Siegel severity scale most ADR were mild (87.65%). The past history of TB and exposure to ATT was the major risk factor associated and was statistically significant (P = 0.009).

Conclusion: ADRs are common in DRTB regimen early recognition and appropriate management might determine treatment adherence, prevent complications, and improve overall treatment outcome.

Key words: Adverse Reactions Monitoring; Multidrug Resistance Tuberculosis; Risk Factors


 
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How to Cite this Article
Pubmed Style

S L, C SS, Ghatage S, B S. Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 339-343. doi:10.5455/njppp.2023.13.07345202324072023


Web Style

S L, C SS, Ghatage S, B S. Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. https://www.njppp.com/?mno=160824 [Access: January 31, 2024]. doi:10.5455/njppp.2023.13.07345202324072023


AMA (American Medical Association) Style

S L, C SS, Ghatage S, B S. Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 339-343. doi:10.5455/njppp.2023.13.07345202324072023



Vancouver/ICMJE Style

S L, C SS, Ghatage S, B S. Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. Natl J Physiol Pharm Pharmacol. (2024), [cited January 31, 2024]; 14(2): 339-343. doi:10.5455/njppp.2023.13.07345202324072023



Harvard Style

S, L., C, . S. S., Ghatage, . S. & B, . S. (2024) Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. Natl J Physiol Pharm Pharmacol, 14 (2), 339-343. doi:10.5455/njppp.2023.13.07345202324072023



Turabian Style

S, Latha, Somashekara S C, Satish Ghatage, and Suraj B. 2024. Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 339-343. doi:10.5455/njppp.2023.13.07345202324072023



Chicago Style

S, Latha, Somashekara S C, Satish Ghatage, and Suraj B. "Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 339-343. doi:10.5455/njppp.2023.13.07345202324072023



MLA (The Modern Language Association) Style

S, Latha, Somashekara S C, Satish Ghatage, and Suraj B. "Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district." National Journal of Physiology, Pharmacy and Pharmacology 14.2 (2024), 339-343. Print. doi:10.5455/njppp.2023.13.07345202324072023



APA (American Psychological Association) Style

S, L., C, . S. S., Ghatage, . S. & B, . S. (2024) Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 339-343. doi:10.5455/njppp.2023.13.07345202324072023