E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice

Manish Mohan, Nirmal George, Shobha P.

Abstract
Background: Monosodium glutamate (MSG), a flavor enhancer, is one of the most widely used commercial food additives. MSG produces oxidative stress in various tissues including cerebellar cortex. There is a paucity if data on the histological and immunohistochemical changes of glial fibrillary acidic protein (GFAP) on chronic administration of MSG at doses equivalent to human consumption (i.e., 40 mg/kg, 60 mg/kg, and 80 mg/kg daily for 3-month duration), hence this study.

Aims and Objectives: The aim of the study was to evaluate the histological and immunohistochemical effects produced by MSG at doses equivalent to human consumption (40mg/kg/day, 60 mg/kg/day, and 80 mg/kg/day) in cerebellar cortex of adult mice.

Materials and Methods: Study commenced after the Institutional Animal Ethics Committee approval. 40 Swiss-albino mice were randomly divided into four groups. Group 1 served as the negative control and received distilled water i.p. Groups 2, 3, and 4 received MSG at increasing doses. Animals were euthanized at 3 months, cerebellar samples were examined histopathologically and immunohistochemically.

Results: Degeneration of the layers of cerebellar cortex in histopathology and reduction in the GFAP activity was observed in immunohistochemistry.

Conclusion: MSG due to its wide consumption can cause degenerative changes in the cerebellum.

Key words: Monosodium Glutamate; Cerebellar Cortex; Histological Effects, Immunohistochemical Effects; Intraperitoneal Administration


 
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Pubmed Style

Mohan M, George N, P S. Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 324-328. doi:10.5455/njppp.2023.13.07340202323072023


Web Style

Mohan M, George N, P S. Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. https://www.njppp.com/?mno=160246 [Access: January 31, 2024]. doi:10.5455/njppp.2023.13.07340202323072023


AMA (American Medical Association) Style

Mohan M, George N, P S. Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 324-328. doi:10.5455/njppp.2023.13.07340202323072023



Vancouver/ICMJE Style

Mohan M, George N, P S. Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. Natl J Physiol Pharm Pharmacol. (2024), [cited January 31, 2024]; 14(2): 324-328. doi:10.5455/njppp.2023.13.07340202323072023



Harvard Style

Mohan, M., George, . N. & P, . S. (2024) Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. Natl J Physiol Pharm Pharmacol, 14 (2), 324-328. doi:10.5455/njppp.2023.13.07340202323072023



Turabian Style

Mohan, Manish, Nirmal George, and Shobha P. 2024. Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 324-328. doi:10.5455/njppp.2023.13.07340202323072023



Chicago Style

Mohan, Manish, Nirmal George, and Shobha P. "Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 324-328. doi:10.5455/njppp.2023.13.07340202323072023



MLA (The Modern Language Association) Style

Mohan, Manish, Nirmal George, and Shobha P. "Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice." National Journal of Physiology, Pharmacy and Pharmacology 14.2 (2024), 324-328. Print. doi:10.5455/njppp.2023.13.07340202323072023



APA (American Psychological Association) Style

Mohan, M., George, . N. & P, . S. (2024) Histological and immunohistochemical effects of chronic intraperitoneal monosodium glutamate at doses equivalent to human consumption in cerebellar cortex of the adult mice. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 324-328. doi:10.5455/njppp.2023.13.07340202323072023