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Original Research 


A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy

Nabanita Dasgupta, Najma Nasrin, Rezina Banu, Kajal Kumar Patra, Pranab Kumar Biswas, Kishore P Madhwani.

Abstract
Background: Premature rupture of membranes (PROM) at term is the term used to describe a spontaneous membrane rupture that occurs after 37 weeks of pregnancy but before the start of regular, painful uterine contractions. Approximately 80% of pregnancies with PROM reach term (5–10% of all pregnancies).

Aim and Objectives: The objective of the study was to associate the results of prostaglandin E2 (PEG2) gel and expectant administration in PROM at term pregnancy in a tertiary care hospital in West Bengal, India.

Materials and Methods: This cross-sectional study was conducted in the Department of Obstetrics and Gynecology, Calcutta National Medical College and Hospital, Kolkata, from February 2020 to July 2021 after obtaining official permission from the Ethics Committee of the institute. Women who were admitted to the labor room were assigned to the research study after obtaining proper consent. The data were statistically analyzed by Microsoft Excel and SPSS version 20 software.

Results: All the patients in the two groups were primigravida and nulliparous. The mean Bishop Score before initiation of management for the patients with expectant management was significantly higher than that of the patients with PEG2 gel. The mean (±standard deviation) induction to active phase interval was 8.62 ± 1.43 h, with a median of 8.25 h, and the range was 6–12 h. Lower uterine segment caesarean section was significantly higher in the PEG2 gel group (24.0%) as compared to the expectant management group (12.0%). Appearance, Pulse, Grimace, Activity, and Respiration scores at 1 min and 5 min of Expectant management were significantly lower than those of the PEG2 gel group. Neonatal intensive care unit admission was comparatively higher in the expectant management group (14.0%) as compared to the PEG2 gel group (4.0%), but it was not significant.

Conclusion: The present study showed early induction by PGE2 gel is an alternative option to manage term PROM mothers because it significantly reduced the PROM to the delivery interval as well as the incidence of maternal and neonatal infection.

Key words: Dinoprostone Gel; Expectant Management; Labour Induction; Premature Rupture of Membranes; Term Pregnancy


 
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How to Cite this Article
Pubmed Style

Dasgupta N, Nasrin N, Banu R, Patra KK, Biswas PK, Madhwani KP. A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 236-241. doi:10.5455/njppp.2023.13.06308202304072023


Web Style

Dasgupta N, Nasrin N, Banu R, Patra KK, Biswas PK, Madhwani KP. A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. https://www.njppp.com/?mno=156601 [Access: January 31, 2024]. doi:10.5455/njppp.2023.13.06308202304072023


AMA (American Medical Association) Style

Dasgupta N, Nasrin N, Banu R, Patra KK, Biswas PK, Madhwani KP. A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. Natl J Physiol Pharm Pharmacol. 2024; 14(2): 236-241. doi:10.5455/njppp.2023.13.06308202304072023



Vancouver/ICMJE Style

Dasgupta N, Nasrin N, Banu R, Patra KK, Biswas PK, Madhwani KP. A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. Natl J Physiol Pharm Pharmacol. (2024), [cited January 31, 2024]; 14(2): 236-241. doi:10.5455/njppp.2023.13.06308202304072023



Harvard Style

Dasgupta, N., Nasrin, . N., Banu, . R., Patra, . K. K., Biswas, . P. K. & Madhwani, . K. P. (2024) A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. Natl J Physiol Pharm Pharmacol, 14 (2), 236-241. doi:10.5455/njppp.2023.13.06308202304072023



Turabian Style

Dasgupta, Nabanita, Najma Nasrin, Rezina Banu, Kajal Kumar Patra, Pranab Kumar Biswas, and Kishore P Madhwani. 2024. A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 236-241. doi:10.5455/njppp.2023.13.06308202304072023



Chicago Style

Dasgupta, Nabanita, Najma Nasrin, Rezina Banu, Kajal Kumar Patra, Pranab Kumar Biswas, and Kishore P Madhwani. "A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 236-241. doi:10.5455/njppp.2023.13.06308202304072023



MLA (The Modern Language Association) Style

Dasgupta, Nabanita, Najma Nasrin, Rezina Banu, Kajal Kumar Patra, Pranab Kumar Biswas, and Kishore P Madhwani. "A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy." National Journal of Physiology, Pharmacy and Pharmacology 14.2 (2024), 236-241. Print. doi:10.5455/njppp.2023.13.06308202304072023



APA (American Psychological Association) Style

Dasgupta, N., Nasrin, . N., Banu, . R., Patra, . K. K., Biswas, . P. K. & Madhwani, . K. P. (2024) A comparative study between intracervical dinoprostone gel and expectant management of premature rupture of membranes in term pregnancy. National Journal of Physiology, Pharmacy and Pharmacology, 14 (2), 236-241. doi:10.5455/njppp.2023.13.06308202304072023