Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial

Utsav Shinghal; Purshottam Kumar Kaundal; Shruti Sharma

doi:10.5455/njppp.2023.13.05290202305062023

2024, Vol: 14, Issue: 10

14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research
Online Published: 13 Jun 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1520-1525

doi: 10.5455/njppp.2023.13.05290202305062023

Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial

Utsav Shinghal, Purshottam Kumar Kaundal, Shruti Sharma.

Abstract
Background: Functional constipation (FC) is a common childhood problem worldwide. At present, polyethylene glycol (PEG) is considered as standard therapy in pediatric FC patients.

Aims and Objectives: The aim of the study was to compare the efficacy of PEG 3350 versus psyllium in treatment of pediatric FC.

Materials and Methods: All children (aged >1 year) diagnosed with FC according to Rome IV criteria and presenting to the outpatient department of Pediatric Gastroenterology, Hepatology, and Nutrition Unit of a tertiary health center in North Indian Himalayan state were randomized into two open label, prospective, parallel groups, namely, Group A (receiving PEG 3350) and Group B (receiving psyllium), over a period of 16 months. The comparative efficacy was evaluated by comparing the percent of patients with successful outcomes in two groups at 4, 8, and 12 weeks of therapy and the rate of recurrence of impaction in two groups was also assessed and compared over same period.

Results: Eighty-one patients were randomized into two groups. A significantly higher number of patients in Group A was successfully treated after 4 weeks (Group A 68.3% vs. Group B 42.5%; P = 0.026), 8 weeks (Group A 80.0% vs. Group B 57.9%; P = 0.049), and 12 weeks (Group A 92.3% vs. Group B 67.6%; P = 0.009) of treatment compared with Group B. Impaction recurred in two patients in Group B while no recurrence was observed in any of the Group A patients but the difference observed was not statistically significant (P = 0.494). No significant adverse events were reported in either groups.

Conclusion: PEG 3350 was found to be significantly more effective than psyllium in improving the symptoms of constipation in pediatric patients.

Key words: Functional Constipation; Polyethylene Glycol; Psyllium; Rome IV Criteria

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Utsav Shinghal Articles by Purshottam Kumar Kaundal Articles by Shruti Sharma
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

Web Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. https://www.njppp.com/?mno=155182 [Access: October 03, 2024]. doi:10.5455/njppp.2023.13.05290202305062023

AMA (American Medical Association) Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

Vancouver/ICMJE Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol. (2023), [cited October 03, 2024]; 13(7): 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

Harvard Style

Shinghal, U., Kaundal, . P. K. & Sharma, . S. (2023) Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol, 13 (7), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

Turabian Style

Shinghal, Utsav, Purshottam Kumar Kaundal, and Shruti Sharma. 2023. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

Chicago Style

Shinghal, Utsav, Purshottam Kumar Kaundal, and Shruti Sharma. "Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

MLA (The Modern Language Association) Style

Shinghal, Utsav, Purshottam Kumar Kaundal, and Shruti Sharma. "Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial." National Journal of Physiology, Pharmacy and Pharmacology 13.7 (2023), 1520-1525. Print. doi:10.5455/njppp.2023.13.05290202305062023

APA (American Psychological Association) Style

Shinghal, U., Kaundal, . P. K. & Sharma, . S. (2023) Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article