Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes

Niveditha Pari; Viji Devanand; Sampathkumari S; Vasantha Kumar M; Anitha D

doi:10.5455/njppp.2023.13.05257202319052023

2024, Vol: 14, Issue: 10

14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research
Online Published: 26 May 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1478-1483

doi: 10.5455/njppp.2023.13.05257202319052023

Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes

Niveditha Pari, Viji Devanand, Sampathkumari S, Vasantha Kumar M, Anitha D.

Abstract
Background: Gestational diabetes mellitus (GDM) is a leading global public health burden affecting up to 12.8% of women. Hyperinsulinemia stimulates adiposity and leptin production. Triglyceride glucose index (TyG) is gaining much acceptance as an indicator of insulin resistance. Very little data are available in the literature regarding the association between insulin resistance and serum leptin concentration in GDM.

Aims and Objectives: The aims of this study were as follows: (1) To find the correlation between TyG index as a marker of insulin resistance and serum leptin levels in GDM. (2) To determine the role of leptin in predicting large for gestational age (LGA) births.

Materials and Methods: In this analytical cross-sectional study, fasting blood samples were taken from 200 GDM women and 200 healthy controls and analyzed for blood glucose, serum triglycerides, and leptin levels. Quantitative leptin assay was done by Sandwich type enzyme immunoassay. TyG index was defined as Ln (fasting triglycerides [mg/dL] × fasting blood glucose [mg/dL]/2).

Results: The mean TyG index and leptin levels were higher in GDM group. There was a weak positive correlation between TyG index and leptin levels which were not statistically significant. Multiple logistic regression analysis showed association between third trimester maternal serum leptin levels and LGA births.

Conclusion: TyG index and leptin levels were elevated in gestational diabetes. Increased maternal leptin levels could increase the risk of LGA births. Further, research is needed to better understand the role of leptin throughout pregnancy and its influence on fetal growth.

Key words: Gestational Diabetes Mellitus; Triglyceride Glucose index; TyG index; Leptin; Large for Gestational Age; LGA; Insulin Resistance

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Niveditha Pari Articles by Viji Devanand Articles by Sampathkumari S Articles by Vasantha Kumar M Articles by Anitha D
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Pari N, Devanand V, S S, M VK, D A. Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

Web Style

Pari N, Devanand V, S S, M VK, D A. Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. https://www.njppp.com/?mno=153218 [Access: October 03, 2024]. doi:10.5455/njppp.2023.13.05257202319052023

AMA (American Medical Association) Style

Pari N, Devanand V, S S, M VK, D A. Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

Vancouver/ICMJE Style

Pari N, Devanand V, S S, M VK, D A. Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. Natl J Physiol Pharm Pharmacol. (2023), [cited October 03, 2024]; 13(7): 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

Harvard Style

Pari, N., Devanand, . V., S, . S., M, . V. K. & D, . A. (2023) Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. Natl J Physiol Pharm Pharmacol, 13 (7), 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

Turabian Style

Pari, Niveditha, Viji Devanand, Sampathkumari S, Vasantha Kumar M, and Anitha D. 2023. Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

Chicago Style

Pari, Niveditha, Viji Devanand, Sampathkumari S, Vasantha Kumar M, and Anitha D. "Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

MLA (The Modern Language Association) Style

Pari, Niveditha, Viji Devanand, Sampathkumari S, Vasantha Kumar M, and Anitha D. "Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes." National Journal of Physiology, Pharmacy and Pharmacology 13.7 (2023), 1478-1483. Print. doi:10.5455/njppp.2023.13.05257202319052023

APA (American Psychological Association) Style

Pari, N., Devanand, . V., S, . S., M, . V. K. & D, . A. (2023) Triglyceride glucose index as a surrogate marker of insulin resistance and its correlation with serum leptin levels in gestational diabetes. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1478-1483. doi:10.5455/njppp.2023.13.05257202319052023

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article