Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study

Ami H Patel; Vilasben K Kavad; Prarthana Kharod Patel; Baldev S Prajapati; Sheena Sivanandan; Vishal Bosamiya; Anjumanben Mansuri

doi:10.5455/njppp.2023.13.03158202305042023

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Online Published: 14 Apr 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(5): 1076-1083

doi: 10.5455/njppp.2023.13.03158202305042023

Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study

Ami H Patel, Vilasben K Kavad, Prarthana Kharod Patel, Baldev S Prajapati, Sheena Sivanandan, Vishal Bosamiya, Anjumanben Mansuri.

Abstract
Background: Enteric fever is a major public health problem in developing countries like India. It affects all age groups but young children are at highest risk. Timely management with appropriate antimicrobial therapy can reduce both morbidity and mortality. In recent years, the emergence of antimicrobial resistance is a significant challenge. Therefore, this study was undertaken to study antibiotic sensitivity pattern of the Salmonella isolates.

Aims and Objectives: The aim of this study was to estimate the prevalence of resistance to commonly used antibiotics in the Salmonella isolates.

Materials and Methods: Children between 6 months and 14 years of age admitted for fever and whose blood culture was positive for Salmonella Typhi or Salmonella Paratyphi A, B, or C were included in the study over a period of 2 years (August 2018–July 2020).

Results: There were 155 patients of enteric fever whose blood culture results were positive for S. Typhi/S. Paratyphi who were included in the study. Out of the 155 culture positive cases, S. Typhi was isolated in 135 (87.1%), S. Paratyphi A in 16 (10.3%) and S. Paratyphi B in 4 (2.6%) cases. All the 135 isolates of S. Typhi were sensitive to cephalosporins. High rate of sensitivity was noted for the first-line drugs – amoxicillin, ampicillin, and trimethoprim-sulfamethoxazole. All 16 isolates of S. Paratyphi A were sensitive to cephalosporins. All the isolates of S. Paratyphi B tested were sensitive to cephalosporins, azithromycin, nalidixic acid, and trimethoprim-sulfamethoxazole.

Conclusion: At present, there is low prevalence of resistance to first-line drugs and third-generation cephalosporins and high resistance to fluoroquinolones, nalidixic acid, and azithromycin as noted in this region. Rational antibiotic selection should be based on sensitivity pattern to prevent emergence of resistant strains.

Key words: Enteric Fever; Antibiotic Resistance; Salmonella Typhi; Salmonella Paratyphi

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How to Cite this Article

Pubmed Style

Patel AH, Kavad VK, Patel PK, Prajapati BS, Sivanandan S, Bosamiya V, Mansuri A. Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2023; 13(5): 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

Web Style

Patel AH, Kavad VK, Patel PK, Prajapati BS, Sivanandan S, Bosamiya V, Mansuri A. Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. https://www.njppp.com/?mno=147581 [Access: September 13, 2024]. doi:10.5455/njppp.2023.13.03158202305042023

AMA (American Medical Association) Style

Patel AH, Kavad VK, Patel PK, Prajapati BS, Sivanandan S, Bosamiya V, Mansuri A. Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2023; 13(5): 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

Vancouver/ICMJE Style

Patel AH, Kavad VK, Patel PK, Prajapati BS, Sivanandan S, Bosamiya V, Mansuri A. Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2023), [cited September 13, 2024]; 13(5): 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

Harvard Style

Patel, A. H., Kavad, . V. K., Patel, . P. K., Prajapati, . B. S., Sivanandan, . S., Bosamiya, . V. & Mansuri, . A. (2023) Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. Natl J Physiol Pharm Pharmacol, 13 (5), 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

Turabian Style

Patel, Ami H, Vilasben K Kavad, Prarthana Kharod Patel, Baldev S Prajapati, Sheena Sivanandan, Vishal Bosamiya, and Anjumanben Mansuri. 2023. Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (5), 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

Chicago Style

Patel, Ami H, Vilasben K Kavad, Prarthana Kharod Patel, Baldev S Prajapati, Sheena Sivanandan, Vishal Bosamiya, and Anjumanben Mansuri. "Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

MLA (The Modern Language Association) Style

Patel, Ami H, Vilasben K Kavad, Prarthana Kharod Patel, Baldev S Prajapati, Sheena Sivanandan, Vishal Bosamiya, and Anjumanben Mansuri. "Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 13.5 (2023), 1076-1083. Print. doi:10.5455/njppp.2023.13.03158202305042023

APA (American Psychological Association) Style

Patel, A. H., Kavad, . V. K., Patel, . P. K., Prajapati, . B. S., Sivanandan, . S., Bosamiya, . V. & Mansuri, . A. (2023) Antibiotic sensitivity profile of the Salmonella isolates in hospitalized children with enteric fever – A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (5), 1076-1083. doi:10.5455/njppp.2023.13.03158202305042023

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