Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats

Venkateshwarlu Yeldandi; Sirisha G; Aditya Jillella; Shwetha Kumari G; Venkata Sahitya Kadiyala; Naga Teja Pavani A

doi:10.5455/njppp.2023.13.02084202316022023

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Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1957-1960

doi: 10.5455/njppp.2023.13.02084202316022023

Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats

Venkateshwarlu Yeldandi, Sirisha G, Aditya Jillella, Shwetha Kumari G, Venkata Sahitya Kadiyala, Naga Teja Pavani A.

Abstract
Background: Pain is an unpleasant sensation, that has limitations with available drugs in terms of effectiveness and safety. Plant-based drugs have gained great importance due to their analgesic, anti-inflammatory and anti-pyretic ability, and limited side effects.

Aim and Objectives: The aim of the study was to evaluate the analgesic effect of Moringa oleifera (drumstick tree) and Tinospora cordifolia (guduchi) leaf extracts in rats.

Materials and methods: This prospective study consists 54 healthy Albino Wistar rats of male sex having weights ranging from 150 to 250 g. Normal saline as control and Tramadol was used as standard. Rats were randomly divided into nine groups (n = 6 in each). Commercially available M. oleifera leaf extracts and T. cordifolia leaf extracts were purchased to check the analgesic effect. Analgesic effect was determined by hot plate method after initial dose and by Tail-immersion method after 15 days of interval.

Results: The reaction time of AMO and ATC with doses 100 mg/kg, 200 mg/kg, 400 mg/kg was 4.28, 4.41, 4.74, and 3.96, 4.12, 4.22 at 90 min, respectively. While, tramadol showed high reaction time at 90 (6.41) and 120 min (7.17). The maximum analgesic effect was found at 90 min by hot plate and tail immersion methods in tramadol group than AMO and AMT.

Conclusion: The aqueous leaf extract of M. oleifera and T. cordifolia has similar analgesic properties. The study drugs have not showed any behavioral or lethal adverse effects during the study.

Key words: Pain; Moringa oleifera; Tinospora cordifolia; Analgesia

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Pubmed Style

Yeldandi V, G S, Jillella A, G SK, Kadiyala VS, A NTP. Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

Web Style

Yeldandi V, G S, Jillella A, G SK, Kadiyala VS, A NTP. Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. https://www.njppp.com/?mno=143544 [Access: September 03, 2023]. doi:10.5455/njppp.2023.13.02084202316022023

AMA (American Medical Association) Style

Yeldandi V, G S, Jillella A, G SK, Kadiyala VS, A NTP. Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

Vancouver/ICMJE Style

Yeldandi V, G S, Jillella A, G SK, Kadiyala VS, A NTP. Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. Natl J Physiol Pharm Pharmacol. (2023), [cited September 03, 2023]; 13(9): 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

Harvard Style

Yeldandi, V., G, . S., Jillella, . A., G, . S. K., Kadiyala, . V. S. & A, . N. T. P. (2023) Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. Natl J Physiol Pharm Pharmacol, 13 (9), 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

Turabian Style

Yeldandi, Venkateshwarlu, Sirisha G, Aditya Jillella, Shwetha Kumari G, Venkata Sahitya Kadiyala, and Naga Teja Pavani A. 2023. Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 13 (9), 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

Chicago Style

Yeldandi, Venkateshwarlu, Sirisha G, Aditya Jillella, Shwetha Kumari G, Venkata Sahitya Kadiyala, and Naga Teja Pavani A. "Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

MLA (The Modern Language Association) Style

Yeldandi, Venkateshwarlu, Sirisha G, Aditya Jillella, Shwetha Kumari G, Venkata Sahitya Kadiyala, and Naga Teja Pavani A. "Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 13.9 (2023), 1957-1960. Print. doi:10.5455/njppp.2023.13.02084202316022023

APA (American Psychological Association) Style

Yeldandi, V., G, . S., Jillella, . A., G, . S. K., Kadiyala, . V. S. & A, . N. T. P. (2023) Evaluation of analgesic properties of Moringa Oleifera and Tinospora Cordifolia leaf extracts on Albino Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 13 (9), 1957-1960. doi:10.5455/njppp.2023.13.02084202316022023

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