E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism

Meenu Gopalakrishnan, Ramidha V P, Sreelakshmi Mohanan, Smrti Salim.

Abstract
Background: Hyperthyroidism, resulting from increased thyroid activity, can affect almost all systems in our body. It can influence the lipid profile as well as numerous other cardiovascular risk factors in an individual.

Aims and Objectives: This study was conducted with the aim of finding out the association between insulin resistance (IR) and serum lipid profiles and serum thyroid-stimulating hormone (TSH) in hyperthyroid patients.

Materials and Methods: A cross-sectional study was conducted among newly diagnosed, untreated hyperthyroid patients and euthyroid bystanders. Serum TSH, serum total cholesterol, serum low density lipoprotein (LDL), serum triglycerides, serum very LDL, serum high-density lipoprotein (HDL), plasma glucose, and serum insulin were assessed. A chi-square test, student’s t-test, and Pearson’s correlation coefficient were done, and a P < 0.05 was considered statistically significant.

Results: In this study, fasting blood glucose, serum insulin, and serum IR were found to be significantly different among the hyperthyroid and euthyroid groups. Mean serum HDL was found to be significantly lower in hyperthyroid patients (38.64 ± 4.69 mg/dL) compared to euthyroid patients (44.44 ± 6.68 mg/dL). A negative correlation between hyperthyroid status and IR was also found (−0.311 [P = 0.040]).

Conclusion: Hyperthyroidism is associated with IR, which can predispose to the emergence of diabetes mellitus. Furthermore, the hyperthyroid state can influence serum HDL levels, which are one of the major components of the lipid profile. Hence, individuals with thyroid dysfunction need to be screened for diabetes as well as dyslipidemia.

Key words: Fasting Blood Sugar; High-density Lipoprotein; Hyperthyroidism; Insulin Resistance; Lipid Profile; Thyroid-Stimulating Hormone


 
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How to Cite this Article
Pubmed Style

Gopalakrishnan M, P RV, Mohanan S, Salim S. Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. Natl J Physiol Pharm Pharmacol. 2023; 13(12): 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023


Web Style

Gopalakrishnan M, P RV, Mohanan S, Salim S. Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. https://www.njppp.com/?mno=141592 [Access: January 31, 2024]. doi:10.5455/njppp.2023.13.01039202315052023


AMA (American Medical Association) Style

Gopalakrishnan M, P RV, Mohanan S, Salim S. Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. Natl J Physiol Pharm Pharmacol. 2023; 13(12): 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023



Vancouver/ICMJE Style

Gopalakrishnan M, P RV, Mohanan S, Salim S. Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. Natl J Physiol Pharm Pharmacol. (2023), [cited January 31, 2024]; 13(12): 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023



Harvard Style

Gopalakrishnan, M., P, . R. V., Mohanan, . S. & Salim, . S. (2023) Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. Natl J Physiol Pharm Pharmacol, 13 (12), 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023



Turabian Style

Gopalakrishnan, Meenu, Ramidha V P, Sreelakshmi Mohanan, and Smrti Salim. 2023. Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. National Journal of Physiology, Pharmacy and Pharmacology, 13 (12), 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023



Chicago Style

Gopalakrishnan, Meenu, Ramidha V P, Sreelakshmi Mohanan, and Smrti Salim. "Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023



MLA (The Modern Language Association) Style

Gopalakrishnan, Meenu, Ramidha V P, Sreelakshmi Mohanan, and Smrti Salim. "Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism." National Journal of Physiology, Pharmacy and Pharmacology 13.12 (2023), 2520-2524. Print. doi:10.5455/njppp.2023.13.01039202315052023



APA (American Psychological Association) Style

Gopalakrishnan, M., P, . R. V., Mohanan, . S. & Salim, . S. (2023) Study of insulin resistance and lipid profile in newly detected cases of hyperthyroidism. National Journal of Physiology, Pharmacy and Pharmacology, 13 (12), 2520-2524. doi:10.5455/njppp.2023.13.01039202315052023