E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A study of chronopharmacological relevance of antihypertensive drugs prescription

Rajeshwari Neela, Priyadarshini Deodurg, Savithri Desai.

Abstract
Background: Chronopharmacology is the “science dealing with the optimization of drug effects and minimization of adverse effects by timing the medications in relation to the biological rhythm.” In patients with hypertension, it is important to maintain a steady blood pressure throughout the day, which necessitates to have knowledge of chronopharmacology and drugs following it. Better understanding of the circadian rhythm and its application for drug administration serves productive utilization of drug.

Aims and Objectives: This study aims to study the chronopharmacological relevance to the time of drug administration in general medicine inpatients at Gulbarga Institute of Medical Sciences, Kalaburagi.

Materials and Methods: It is a prospective, non-interventional, observational study which was conducted on patients admitted in General Medicine wards at GIMS, Kalaburagi. A special pro forma was designed, and data were obtained from medical case records of patients suffering from various disorders admitted in the wards of general medicine. Demographic data, disease data, data pertaining to drug therapy, data pertaining to other comorbid illness, and adverse effects of drugs, if any, were collected. Descriptive statistics and other suitable statistical test were applied for analyzing the data.

Results: A total of 110 patients who were on antihypertensive drugs and who meet the inclusion and exclusion criteria of the study were included in the study. The average age of both male and female was found to be between 45 and 68 years. Among 110 patients, 72 (65.45%) were male and 38 (34.54%) were female. In the current study, a total of 124 wide variety of antihypertensive drugs were recorded. The study of ideal time of administration of all antihypertensive drugs showed that, most of the prescription was according to chronopharmacological relevance.

Conclusion: Updating the knowledge of chronopharmacology and its application in clinical practice will provide better health care. The current study highlights the importance of timing of administration of antihypertensive drugs in human health care.

Key words: Antihypertensive Drugs; Chronotherapy; Hypertension


 
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How to Cite this Article
Pubmed Style

Neela R, Deodurg P, Desai S. A study of chronopharmacological relevance of antihypertensive drugs prescription. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022


Web Style

Neela R, Deodurg P, Desai S. A study of chronopharmacological relevance of antihypertensive drugs prescription. https://www.njppp.com/?mno=140578 [Access: November 24, 2022]. doi:10.5455/njppp.2022.12.0107202211012022


AMA (American Medical Association) Style

Neela R, Deodurg P, Desai S. A study of chronopharmacological relevance of antihypertensive drugs prescription. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022



Vancouver/ICMJE Style

Neela R, Deodurg P, Desai S. A study of chronopharmacological relevance of antihypertensive drugs prescription. Natl J Physiol Pharm Pharmacol. (2022), [cited November 24, 2022]; 12(9): 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022



Harvard Style

Neela, R., Deodurg, . P. & Desai, . S. (2022) A study of chronopharmacological relevance of antihypertensive drugs prescription. Natl J Physiol Pharm Pharmacol, 12 (9), 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022



Turabian Style

Neela, Rajeshwari, Priyadarshini Deodurg, and Savithri Desai. 2022. A study of chronopharmacological relevance of antihypertensive drugs prescription. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022



Chicago Style

Neela, Rajeshwari, Priyadarshini Deodurg, and Savithri Desai. "A study of chronopharmacological relevance of antihypertensive drugs prescription." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022



MLA (The Modern Language Association) Style

Neela, Rajeshwari, Priyadarshini Deodurg, and Savithri Desai. "A study of chronopharmacological relevance of antihypertensive drugs prescription." National Journal of Physiology, Pharmacy and Pharmacology 12.9 (2022), 1344-1347. Print. doi:10.5455/njppp.2022.12.0107202211012022



APA (American Psychological Association) Style

Neela, R., Deodurg, . P. & Desai, . S. (2022) A study of chronopharmacological relevance of antihypertensive drugs prescription. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1344-1347. doi:10.5455/njppp.2022.12.0107202211012022