E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of antidepressant activity of ondansetron in rodent models of depression

Vipin Kumar Jain, Shilpa Navinchandra Kaore, Nitin Kumar Jain, Megha Jain, Ritesh Upadhyay.

Abstract
Background: At present, there is an escalating concern regarding possible role of 5-HT3 receptor in psychopharmacology and the therapeutic potential of their antagonists. Moreover, inclusion of 5-HT3 receptor antagonist may curtail the antidepressant-induced LTP decrease causing memory deficits, thereby improving efficacy of current antidepressants.

Aim and Objective: This study aims to evaluate the antidepressant activity of 5-HT3 antagonist, that is, ondansetron (OND) in rodent models of depression.

Materials and Methods: Male Swiss albino mice (20–30 g bw) and Wistar rats (100–200 g bw) were divided into five groups. Animals received either OND p.o. (0.1, 0.5 and 1 mg/kg), venlafaxine (10 mg/kg), or vehicle (1 ml distilled water p.o.) in control. Tail suspension and forced swim test were used to evaluate the effects of drugs and control after 60 min of their administration. Furthermore, assessment of locomotor activity (LA) was done by photoactometer after 24 h of drug administration.

Results: Ondansetron exhibited significant antidepressants activity (P < 0.05) in rodent models. However, LA was not significantly altered by OND.

Conclusion: Ondansetron exhibited significant antidepressant activity in rodent models hence paving the way for exploration of 5-HT3 receptor antagonist in future researches and its therapeutic application in depression.

Key words: 5-HT3; Antidepressants; Psychopharmacology; Long-Term Potentiation


 
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How to Cite this Article
Pubmed Style

Jain VK, Kaore SN, Jain NK, Jain M, Upadhyay R. Evaluation of antidepressant activity of ondansetron in rodent models of depression. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 576-580. doi:10.5455/njppp.2022.12.10378202123102021


Web Style

Jain VK, Kaore SN, Jain NK, Jain M, Upadhyay R. Evaluation of antidepressant activity of ondansetron in rodent models of depression. https://www.njppp.com/?mno=133227 [Access: May 02, 2022]. doi:10.5455/njppp.2022.12.10378202123102021


AMA (American Medical Association) Style

Jain VK, Kaore SN, Jain NK, Jain M, Upadhyay R. Evaluation of antidepressant activity of ondansetron in rodent models of depression. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 576-580. doi:10.5455/njppp.2022.12.10378202123102021



Vancouver/ICMJE Style

Jain VK, Kaore SN, Jain NK, Jain M, Upadhyay R. Evaluation of antidepressant activity of ondansetron in rodent models of depression. Natl J Physiol Pharm Pharmacol. (2022), [cited May 02, 2022]; 12(5): 576-580. doi:10.5455/njppp.2022.12.10378202123102021



Harvard Style

Jain, V. K., Kaore, . S. N., Jain, . N. K., Jain, . M. & Upadhyay, . R. (2022) Evaluation of antidepressant activity of ondansetron in rodent models of depression. Natl J Physiol Pharm Pharmacol, 12 (5), 576-580. doi:10.5455/njppp.2022.12.10378202123102021



Turabian Style

Jain, Vipin Kumar, Shilpa Navinchandra Kaore, Nitin Kumar Jain, Megha Jain, and Ritesh Upadhyay. 2022. Evaluation of antidepressant activity of ondansetron in rodent models of depression. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 576-580. doi:10.5455/njppp.2022.12.10378202123102021



Chicago Style

Jain, Vipin Kumar, Shilpa Navinchandra Kaore, Nitin Kumar Jain, Megha Jain, and Ritesh Upadhyay. "Evaluation of antidepressant activity of ondansetron in rodent models of depression." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 576-580. doi:10.5455/njppp.2022.12.10378202123102021



MLA (The Modern Language Association) Style

Jain, Vipin Kumar, Shilpa Navinchandra Kaore, Nitin Kumar Jain, Megha Jain, and Ritesh Upadhyay. "Evaluation of antidepressant activity of ondansetron in rodent models of depression." National Journal of Physiology, Pharmacy and Pharmacology 12.5 (2022), 576-580. Print. doi:10.5455/njppp.2022.12.10378202123102021



APA (American Psychological Association) Style

Jain, V. K., Kaore, . S. N., Jain, . N. K., Jain, . M. & Upadhyay, . R. (2022) Evaluation of antidepressant activity of ondansetron in rodent models of depression. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 576-580. doi:10.5455/njppp.2022.12.10378202123102021