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2023, Vol: 13, Issue: 9
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Original Research 


A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology

Jayita Dasgupta (Ghosh), Sambit Dasgupta, Jayashree Konar.

Abstract
Background: Bacterial meningitis is a global public health issue. C-reactive protein (CRP) has suitable diagnostic value in distinguishing between bacterial and aseptic meningitis especially in cases of negative bacterial culture of the blood and spinal fluid.

Aim and Objective: The objective of this study was to estimate the serum level of CRP among pediatric meningitis cases with bacterial etiology.

Materials and Methods: The hospital-based descriptive cross-sectional study was performed in a tertiary care pediatric hospital in Eastern India from June to August, 2021 with 150 samples. Patients fulfilling the inclusion criteria were selected for this study after obtaining informed consent. Cerebrospinal fluid sample was collected as per standard guidelines. Phenotypic identification of bacteria including antimicrobial susceptibility testing was done by automation (Vitek 2 compact, bioMerieux). Quantitative estimation of CRP was performed in a solid phase and sandwich-format immunometric assay using a gold antibody conjugate. Human rights, welfare, and autonomy were protected as per national ethical guidelines.

Results: Median age (Inter Quartile Range) of 150 cases was 3(1–4.5) year. Escherichia coli (60.52%, 23/38) was the commonest isolate (P < 0.00000001 by Binomial test calculation) followed by Klebsiella pneumoniae (34.24%, i.e., 13/38). A total of 43/150 (28.66%) participants had higher serum CRP. Serum CRP was raised more in Gram-negative bacterial etiology (36 out of 38, 94.73%). Mean serum CRP was higher in Gram-negative cases (P < 0.05).

Conclusion: Serum CRP was found significantly higher in meningitis caused by Gram-negative bacteria.

Key words: C-Reactive Protein; Meningitis; Gram-Negative; Gram-Positive


 
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How to Cite this Article
Pubmed Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Web Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. https://www.njppp.com/?mno=127931 [Access: September 03, 2023]. doi:10.5455/njppp.2023.13.11527202216112022

AMA (American Medical Association) Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022


Vancouver/ICMJE Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol. (2023), [cited September 03, 2023]; 13(6): 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022


Harvard Style

(Ghosh), J. D., Dasgupta, . S. & Konar, . J. (2023) A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol, 13 (6), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022


Turabian Style

(Ghosh), Jayita Dasgupta, Sambit Dasgupta, and Jayashree Konar. 2023. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022


Chicago Style

(Ghosh), Jayita Dasgupta, Sambit Dasgupta, and Jayashree Konar. "A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022


MLA (The Modern Language Association) Style

(Ghosh), Jayita Dasgupta, Sambit Dasgupta, and Jayashree Konar. "A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology." National Journal of Physiology, Pharmacy and Pharmacology 13.6 (2023), 1205-1208. Print. doi:10.5455/njppp.2023.13.11527202216112022


APA (American Psychological Association) Style

(Ghosh), J. D., Dasgupta, . S. & Konar, . J. (2023) A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022


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