E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection

Debasis Mukhopadhyay, Arup Chakraborty, Sunita Bagdi, Aparajita Samaddar, Swapan Pathak.

Abstract
Background: Hemoglobinopathies are the major cause of anemia throughout the world complicating pregnancy outcome. Hence, detection of hemoglobinopathies in antenatal period is of critical importance as it not only predict the possibility of birth of a child with thalassemia but also reduces the complications associated with anemia in pregnancy. Hence, identification of a reliable cost-effective screening method for detection of hemoglobinopathies is of utmost importance.

Aims and Objectives: The present study was conducted to evaluate the role of red blood cell (RBC) parameters including hemoglobin (Hb%), RBC count, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) in detection of thalassemia carriers among healthy antenatal mothers in a tertiary care hospital of Eastern India.

Materials and Methods: Venous blood samples were collected from total 1458 antenatal mothers aged 18 years or above with <17 weeks of gestation and were analyzed for complete blood count, serum ferritin level, and high-performance liquid chromatography for identification of abnormal Hb. Patients with iron deficiency anemia as diagnosed by serum ferritin <15 ng/ml were excluded from this study.

Results: The prevalence of hemoglobinopathy was found to be 12.55% with ß-thalassemia trait (BTT) being the most common type (7.9%). All the RBC parameters were significantly lower among the BTT group compared to individuals with normal or other hemoglobinopathies (P < 0.05).

Conclusion: RBC parameters such as Hb, RBC, MCV, and MCH can be used as cost-effective yet very effective screening method to identify different hemoglobinopathies among antenatal mothers.

Key words: Antenatal Mothers; Thalassemia; Red Blood Cell Indices


 
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How to Cite this Article
Pubmed Style

Mukhopadhyay D, Chakraborty A, Bagdi S, Samaddar A, Pathak S. Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022


Web Style

Mukhopadhyay D, Chakraborty A, Bagdi S, Samaddar A, Pathak S. Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. https://www.njppp.com/?mno=125575 [Access: February 01, 2023]. doi:10.5455/njppp.2022.12.10510202204112022


AMA (American Medical Association) Style

Mukhopadhyay D, Chakraborty A, Bagdi S, Samaddar A, Pathak S. Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022



Vancouver/ICMJE Style

Mukhopadhyay D, Chakraborty A, Bagdi S, Samaddar A, Pathak S. Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. Natl J Physiol Pharm Pharmacol. (2022), [cited February 01, 2023]; 12(12): 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022



Harvard Style

Mukhopadhyay, D., Chakraborty, . A., Bagdi, . S., Samaddar, . A. & Pathak, . S. (2022) Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. Natl J Physiol Pharm Pharmacol, 12 (12), 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022



Turabian Style

Mukhopadhyay, Debasis, Arup Chakraborty, Sunita Bagdi, Aparajita Samaddar, and Swapan Pathak. 2022. Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022



Chicago Style

Mukhopadhyay, Debasis, Arup Chakraborty, Sunita Bagdi, Aparajita Samaddar, and Swapan Pathak. "Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022



MLA (The Modern Language Association) Style

Mukhopadhyay, Debasis, Arup Chakraborty, Sunita Bagdi, Aparajita Samaddar, and Swapan Pathak. "Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 2167-2171. Print. doi:10.5455/njppp.2022.12.10510202204112022



APA (American Psychological Association) Style

Mukhopadhyay, D., Chakraborty, . A., Bagdi, . S., Samaddar, . A. & Pathak, . S. (2022) Pattern of hemoglobinopathies in females attending in antenatal clinic with special reference to the role of RBC parameters in beta-thalassemia carrier detection. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2167-2171. doi:10.5455/njppp.2022.12.10510202204112022