E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model

Houndjo Salimata Diagne, Sène Madieye, Sarr Abdou, Coly Mame Saloum, Diaw Mor, Sow Abdou K, Sar Fatou Bintou, Samb Abdoulaye.

Abstract
Background: The mastery and supervision of traditional medicine in our country, particularly Senegal, would be of capital importance for the population. We were interested in the physiological effects of Voacanga africana (VOC) extracts in wound healing and topical inflammation.

Aims and Objectives: This work was to evaluate the effects on inflammation and tissue repair of an hydroethanolic extract of V. africana.

Materials and Methods: Wounds were created from a rat burn model and wound healing was evaluated (Kamoshida method) topical inflammation in a murine model of croton oil-induced inflammatory edema. For each experiment, batches of rats or of a mouse were formed, and every batch included five animals.

Results: VOC’s 30% root bark ointment showed complete healing by day 16 for the burn test. As for inflammation, the 10% ointment inhibits 80% of the inflammatory edema in the same manner as indomethacin, used as the standard anti-inflammatory drug.

Conclusion: VOC could have dose-dependent effects on inflammation and burn healing.

Key words: Voacanga africana; Root Bark; Healing; Inflammation


 
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How to Cite this Article
Pubmed Style

Diagne HS, Madieye S, Abdou S, Saloum CM, Mor D, K SA, Bintou SF, Abdoulaye S. Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 151-156. doi:10.5455/njppp.2023.13.11545202224112022


Web Style

Diagne HS, Madieye S, Abdou S, Saloum CM, Mor D, K SA, Bintou SF, Abdoulaye S. Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. https://www.njppp.com/?mno=124452 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.11545202224112022


AMA (American Medical Association) Style

Diagne HS, Madieye S, Abdou S, Saloum CM, Mor D, K SA, Bintou SF, Abdoulaye S. Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 151-156. doi:10.5455/njppp.2023.13.11545202224112022



Vancouver/ICMJE Style

Diagne HS, Madieye S, Abdou S, Saloum CM, Mor D, K SA, Bintou SF, Abdoulaye S. Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 151-156. doi:10.5455/njppp.2023.13.11545202224112022



Harvard Style

Diagne, H. S., Madieye, . S., Abdou, . S., Saloum, . C. M., Mor, . D., K, . S. A., Bintou, . S. F. & Abdoulaye, . S. (2023) Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. Natl J Physiol Pharm Pharmacol, 13 (1), 151-156. doi:10.5455/njppp.2023.13.11545202224112022



Turabian Style

Diagne, Houndjo Salimata, Sène Madieye, Sarr Abdou, Coly Mame Saloum, Diaw Mor, Sow Abdou K, Sar Fatou Bintou, and Samb Abdoulaye. 2023. Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 151-156. doi:10.5455/njppp.2023.13.11545202224112022



Chicago Style

Diagne, Houndjo Salimata, Sène Madieye, Sarr Abdou, Coly Mame Saloum, Diaw Mor, Sow Abdou K, Sar Fatou Bintou, and Samb Abdoulaye. "Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 151-156. doi:10.5455/njppp.2023.13.11545202224112022



MLA (The Modern Language Association) Style

Diagne, Houndjo Salimata, Sène Madieye, Sarr Abdou, Coly Mame Saloum, Diaw Mor, Sow Abdou K, Sar Fatou Bintou, and Samb Abdoulaye. "Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 151-156. Print. doi:10.5455/njppp.2023.13.11545202224112022



APA (American Psychological Association) Style

Diagne, H. S., Madieye, . S., Abdou, . S., Saloum, . C. M., Mor, . D., K, . S. A., Bintou, . S. F. & Abdoulaye, . S. (2023) Anti-inflammatory and healing activity of an hydroethanolic extract of Voacanga africana stapt ex Scoot-Elliot (Apocynaceae): In vivo model. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 151-156. doi:10.5455/njppp.2023.13.11545202224112022