E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A study of coagulation profile in preeclampsia compared to normal pregnancy

Sumera Tasleem, Syed Imran Ali, Mohd Noorjahan Begum.

Abstract
Background: Preeclampsia is a condition of unknown etiology of multiorgan disease and is distinguished by a raised blood pressure (B.P. >140/90 mmHg) and proteinuria (>300 mg per 24 h) and/or edema following 20 weeks of pregnancy.

Aims and Objectives: The study was conducted to differentiate coagulation variables between normotensives and preeclamptic patients.

Materials and Methods: Prior consent was obtained from Institutional Ethics Committee. Patients diagnosed with preeclampsia aged between 20 and 35 years were incorporated into the study. Patients with a previous history of hypertension, thyroid disease, and diabetes were excluded from the study. Age-matched controls were taken and analyzed. Data collection done by (i) BP measured in supine posture; (ii) bleeding time (B.T) estimation – by Duke’s method; (iii) clotting time (C.T) estimation – by Wright’s capillary tube method; (iv) platelet count (P.C) estimation – by automated hematology analyzer; and (v) prothrombin time (P.T) and activated partial thromboplastin time (APTT) – estimation by semi-automated analyzer.

Results: The study revealed a significant interrelation between P.C and B.T when preeclampsia patients were correlated with normotensives patients while P.T, APTT, and C.T were insignificant statistically.

Conclusion: A statistically significant change was observed proposing parameters derangement as the disease becomes more progressive.

Key words: Preeclampsia; Platelet Count; Bleeding Time; Clotting Time; Prothrombin Time; Activated Partial Thromboplastin Time


 
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Pubmed Style

Tasleem S, Ali SI, Begum MN. A study of coagulation profile in preeclampsia compared to normal pregnancy. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022


Web Style

Tasleem S, Ali SI, Begum MN. A study of coagulation profile in preeclampsia compared to normal pregnancy. https://www.njppp.com/?mno=12118 [Access: February 01, 2023]. doi:10.5455/njppp.2022.12.04165202213042022


AMA (American Medical Association) Style

Tasleem S, Ali SI, Begum MN. A study of coagulation profile in preeclampsia compared to normal pregnancy. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022



Vancouver/ICMJE Style

Tasleem S, Ali SI, Begum MN. A study of coagulation profile in preeclampsia compared to normal pregnancy. Natl J Physiol Pharm Pharmacol. (2022), [cited February 01, 2023]; 12(12): 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022



Harvard Style

Tasleem, S., Ali, . S. I. & Begum, . M. N. (2022) A study of coagulation profile in preeclampsia compared to normal pregnancy. Natl J Physiol Pharm Pharmacol, 12 (12), 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022



Turabian Style

Tasleem, Sumera, Syed Imran Ali, and Mohd Noorjahan Begum. 2022. A study of coagulation profile in preeclampsia compared to normal pregnancy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022



Chicago Style

Tasleem, Sumera, Syed Imran Ali, and Mohd Noorjahan Begum. "A study of coagulation profile in preeclampsia compared to normal pregnancy." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022



MLA (The Modern Language Association) Style

Tasleem, Sumera, Syed Imran Ali, and Mohd Noorjahan Begum. "A study of coagulation profile in preeclampsia compared to normal pregnancy." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 2037-2041. Print. doi:10.5455/njppp.2022.12.04165202213042022



APA (American Psychological Association) Style

Tasleem, S., Ali, . S. I. & Begum, . M. N. (2022) A study of coagulation profile in preeclampsia compared to normal pregnancy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2037-2041. doi:10.5455/njppp.2022.12.04165202213042022