Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study

Bhuvaneswari S; Suresh Bhalaji S; Sarath Babu Kurra; Nasrin Nisha A

doi:10.5455/njppp.2023.13.094732022002112022

2023, Vol: 13, Issue: 9

13 / 9Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

Original Research

Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1140-1145

doi: 10.5455/njppp.2023.13.094732022002112022

Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study

Bhuvaneswari S, Suresh Bhalaji S, Sarath Babu Kurra, Nasrin Nisha A.

Abstract
Background: This study was conducted to evaluate the effect of various oral hypoglycemic agents in the control of plasma blood glucose levels among Type 2 diabetes mellitus (T2DM) patients.

Aims and Objectives: This study is aimed to evaluate the blood glucose controlling efficacy of various oral hypoglycemic drugs in T2DM patients.

Materials and Methods: This randomized and control study was conducted among the cases attending Department of General Medicine at Research cell of Chennai Medical College Hospital and Research Centre, during the period of June 2014 to July 2015. A total of 180 cases were randomly allotted to six groups. Group I was treated with Glibenclamide, Group-II was treated with Glibenclamide + Sitagliptin, Group-III was treated with Glibenclamide + Vildagliptin, Group-IV was treated with Metformin, Group-V was treated with Metformin + Sitagliptin, and Group-VI was treated with Metformin + Vildagliptin. Fasting, postprandial, and glycated hemoglobin (HbA1c) levels were assessed before and at 4, 8, and 12th weeks and the data were analyzed using Statistical Package for the Social Sciences.

Results: Fasting and postprandial sugars were significantly reduced in Group V and Group VI during 4th, 8th, and 12th weeks. However, HbA1c levels were significantly reduced after 12 weeks of treatment in Group III, Group V, and Group VI.

Conclusion: We conclude that metformin in combination with either Vildagliptin or Sitagliptin can help to reduce fasting, postprandial, and HbA1c levels (both in short-term and in long-term); however, Glibenclamide along with Vildagliptin could reduce only HbA1c levels (long-term alone).

Key words: Glycemic Levels; Vildagliptin; Sitagliptin; Oral Hypoglycemic Agents; Hypoglycemia; Diabetes Mellitus

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Bhuvaneswari S Articles by Suresh Bhalaji S Articles by Sarath Babu Kurra Articles by Nasrin Nisha A
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

Web Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. https://www.njppp.com/?mno=118286 [Access: September 03, 2023]. doi:10.5455/njppp.2023.13.094732022002112022

AMA (American Medical Association) Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

Vancouver/ICMJE Style

S B, S SB, Kurra SB, A NN. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol. (2023), [cited September 03, 2023]; 13(6): 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

Harvard Style

S, B., S, . S. B., Kurra, . S. B. & A, . N. N. (2023) Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. Natl J Physiol Pharm Pharmacol, 13 (6), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

Turabian Style

S, Bhuvaneswari, Suresh Bhalaji S, Sarath Babu Kurra, and Nasrin Nisha A. 2023. Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

Chicago Style

S, Bhuvaneswari, Suresh Bhalaji S, Sarath Babu Kurra, and Nasrin Nisha A. "Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

MLA (The Modern Language Association) Style

S, Bhuvaneswari, Suresh Bhalaji S, Sarath Babu Kurra, and Nasrin Nisha A. "Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study." National Journal of Physiology, Pharmacy and Pharmacology 13.6 (2023), 1140-1145. Print. doi:10.5455/njppp.2023.13.094732022002112022

APA (American Psychological Association) Style

S, B., S, . S. B., Kurra, . S. B. & A, . N. N. (2023) Evaluation of blood glucose controlling efficacy of various oral hypoglycemic drugs in Type 2 diabetes mellitus patients: A prospective, randomized, and control study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1140-1145. doi:10.5455/njppp.2023.13.094732022002112022

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information



About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article