The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study

Narayanan Puthiya Veettil; Varun Raghavan Kallakudiyan; Anu Chandran Nirichan

doi:10.5455/njppp.2023.13.094632022026102022

2023, Vol: 13, Issue: 5

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Natl J Physiol Pharm Pharmacol. 2023; 13(5): 1118-1121

doi: 10.5455/njppp.2023.13.094632022026102022

The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study

Narayanan Puthiya Veettil, Varun Raghavan Kallakudiyan, Anu Chandran Nirichan.

Abstract
Background: COVID-19 has appeared as a pandemic and public health issue at a universal level. First documented as a respiratory disease, COVID-19 has been found to interrelate with and disturb the cardiovascular system causing myocardial injury and also cardiac dysfunction. Initial documentation of cardiac pathology can play a substantial role in dropping the death rate. This study emphasizes on the relationship between the serum levels of cardiac Trop I and prognosis in patients with and without pre-existing CAD in COVID-19 patients.

Aims and Objectives: The first objective was to explore the association among the serum levels of cardiac Trop I and bad prognosis in patients with antiquity of CAD and without CAD. The secondary objective was to explore and understand whether increased Trop I is an appreciated prognostic indicator for COVID-19 patient antagonistic prognosis.

Materials and Methods: This was conducted as a retrospective observational study in which a whole of 45 patients admitted in COVID Hospital of Malabar Medical College and Research Center category C were studied. The medical record of the patients whose COVID-19 confirmation done by combined conclusions of reverse transcription PCR, symptoms, and chest X-ray was studies by the team.

Results: Mean age of the study participants was 59.3 ± 13.7. Every study participants had elevated Trop I levels with a median Trop I in study subjects being 397.9. There was a statistically significant elevation in Trop I levels in patients with CAD linked with non-CAD patients with a median IQR of 641.6 and P = 0.003 and there was a significant increase in Trop I levels in patients who expired related to patients who got discharged with a median IQR of 587.3 and P = 0.003.

Conclusion: From this study, we accomplish that rise in cardiac troponin-I level is connected with elevated mortality in patients with COVID-19. Hence, it can be used as significant biomarker of disease evolution, hospitalization, and worse prognosis in COVID-19 patients.

Key words: Coronary Artery Disease; COVID-19; Mortality; Troponin I

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Pubmed Style

Veettil NP, Kallakudiyan VR, Nirichan AC. The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. Natl J Physiol Pharm Pharmacol. 2023; 13(5): 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

Web Style

Veettil NP, Kallakudiyan VR, Nirichan AC. The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. https://www.njppp.com/?mno=117982 [Access: May 01, 2023]. doi:10.5455/njppp.2023.13.094632022026102022

AMA (American Medical Association) Style

Veettil NP, Kallakudiyan VR, Nirichan AC. The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. Natl J Physiol Pharm Pharmacol. 2023; 13(5): 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

Vancouver/ICMJE Style

Veettil NP, Kallakudiyan VR, Nirichan AC. The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. Natl J Physiol Pharm Pharmacol. (2023), [cited May 01, 2023]; 13(5): 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

Harvard Style

Veettil, N. P., Kallakudiyan, . V. R. & Nirichan, . A. C. (2023) The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. Natl J Physiol Pharm Pharmacol, 13 (5), 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

Turabian Style

Veettil, Narayanan Puthiya, Varun Raghavan Kallakudiyan, and Anu Chandran Nirichan. 2023. The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (5), 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

Chicago Style

Veettil, Narayanan Puthiya, Varun Raghavan Kallakudiyan, and Anu Chandran Nirichan. "The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

MLA (The Modern Language Association) Style

Veettil, Narayanan Puthiya, Varun Raghavan Kallakudiyan, and Anu Chandran Nirichan. "The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study." National Journal of Physiology, Pharmacy and Pharmacology 13.5 (2023), 1118-1121. Print. doi:10.5455/njppp.2023.13.094632022026102022

APA (American Psychological Association) Style

Veettil, N. P., Kallakudiyan, . V. R. & Nirichan, . A. C. (2023) The association between the elevated serum levels of cardiac Trop I and mortality in patients with and without pre-existing CAD in COVID-19 patients: A retrospective observational study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (5), 1118-1121. doi:10.5455/njppp.2023.13.094632022026102022

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