Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre

Shanavas A; Shaiji Panthiyil Shahul Hameed; Meena Dharmadas; Mayadevi S

doi:10.5455/njppp.2023.13.09431202221092022

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Original Research
Online Published: 05 Oct 2022

Natl J Physiol Pharm Pharmacol. 2023; 13(5): 939-944

doi: 10.5455/njppp.2023.13.09431202221092022

Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre

Shanavas A, Shaiji Panthiyil Shahul Hameed, Meena Dharmadas, Mayadevi S.

Abstract
Background: Researchers have studied the hemodynamic effect of hemorrhage widely but the biochemical alternations after blood loss are less explored. Knowledge about changes in electrolyte values after blood donation may help in assessing the effect on large quantity donations or massive hemorrhage. It may also be beneficial in donor counseling and reassurance.

Aims and Objectives: Primary objective of the study was to quantify changes in plasma sodium, potassium, calcium, magnesium, and albumin before and after blood donation.

Materials and Methods: Predonation electrolyte and albumin levels were tested in all study subjects as baseline and repeated after 45 min of completed blood donation. Both values were compared with paired t test in SPSS version 17.

Results: After 45 min of donating 350 ml whole blood, no significant changes were observed in sodium and potassium levels. Reduction in calcium, magnesium, and albumin was 0.188 mg/dL, 0.0328 mg/dl, and 0.193 g/dl, respectively, which were statistically significant. About 15% of the blood donors were already deficient in magnesium.

Conclusions: Calcium, magnesium, and albumin levels were reduced after blood donation but well maintained within the normal level and most of the donors had normal predonation levels. Hence, in large volume or repeated plasma donation and massive blood loss, baseline evaluation, and monitoring of these parameters may be worthwhile.

Key words: Hemorrhage; Blood Donors; Electrolytes; Albumins

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Pubmed Style

A S, Hameed SPS, Dharmadas M, S M. Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. Natl J Physiol Pharm Pharmacol. 2023; 13(5): 939-944. doi:10.5455/njppp.2023.13.09431202221092022

Web Style

A S, Hameed SPS, Dharmadas M, S M. Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. https://www.njppp.com/?mno=112662 [Access: April 17, 2025]. doi:10.5455/njppp.2023.13.09431202221092022

AMA (American Medical Association) Style

A S, Hameed SPS, Dharmadas M, S M. Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. Natl J Physiol Pharm Pharmacol. 2023; 13(5): 939-944. doi:10.5455/njppp.2023.13.09431202221092022

Vancouver/ICMJE Style

A S, Hameed SPS, Dharmadas M, S M. Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. Natl J Physiol Pharm Pharmacol. (2023), [cited April 17, 2025]; 13(5): 939-944. doi:10.5455/njppp.2023.13.09431202221092022

Harvard Style

A, S., Hameed, . S. P. S., Dharmadas, . M. & S, . M. (2023) Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. Natl J Physiol Pharm Pharmacol, 13 (5), 939-944. doi:10.5455/njppp.2023.13.09431202221092022

Turabian Style

A, Shanavas, Shaiji Panthiyil Shahul Hameed, Meena Dharmadas, and Mayadevi S. 2023. Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. National Journal of Physiology, Pharmacy and Pharmacology, 13 (5), 939-944. doi:10.5455/njppp.2023.13.09431202221092022

Chicago Style

A, Shanavas, Shaiji Panthiyil Shahul Hameed, Meena Dharmadas, and Mayadevi S. "Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 939-944. doi:10.5455/njppp.2023.13.09431202221092022

MLA (The Modern Language Association) Style

A, Shanavas, Shaiji Panthiyil Shahul Hameed, Meena Dharmadas, and Mayadevi S. "Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre." National Journal of Physiology, Pharmacy and Pharmacology 13.5 (2023), 939-944. Print. doi:10.5455/njppp.2023.13.09431202221092022

APA (American Psychological Association) Style

A, S., Hameed, . S. P. S., Dharmadas, . M. & S, . M. (2023) Effect of controlled loss of 350 ml blood from human body on electrolytes and albumin levels – An observational study done in whole blood donors at a regional blood centre. National Journal of Physiology, Pharmacy and Pharmacology, 13 (5), 939-944. doi:10.5455/njppp.2023.13.09431202221092022

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