E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Analysis of drug use in patients of analgesic nephropathy

Inderpal Singh Grover, Deepa Latha C, Raja Vikram Prasad, Suvarchala Satyagama.

Abstract
Background: The global incidence and prevalence of analgesic nephropathy is 28% in 1981 and 12% in 1990. Intake of 68 tablets per day for 68 years attributes to development of analgesic nephropathy. This article serves caution and reminder about unnoticed renal threat posed by long-term use of analgesics.

Aim and Objectives: The study objective is to assess the drug utilization pattern in patients of analgesic nephropathy.

Materials and Methods: It is a cross-sectional observational study, carried out across multicenter under the tertiary care hospital, after obtaining permission from respective institutes. Data were collected on demographic features such as age, gender, duration, and type of analgesics used by patients from various monitoring centers through CDSCO forms. To analyze the drug utilization pattern, the World Health Organization prescribing indicator scales were applied.

Results: A total of 32 patient case sheets were analyzed, showing more of females (65.6%) being affected compared to men. Involving more patients aged above 3150 years (50%). 5170 years (37.5%) being affected with cyclooxygenase (COX-2) inhibitors along with nonselective COX inhibitors. The most common prescribed are COX-2 inhibitors such as Diclofenac and Aceclofenac along with combination of Paracetamol. 40.4% patients were affected with fixed drug combinations and usage of drugs between 2 and 6 months were 34.4%. 56% landed with acute renal failure and 44% were progressed to end stage renal disease.

Conclusions: Usage and prescribing of analgesics were more of irrational combinations and patients taking self-medication for long duration were against the WHO standards.

Key words: Drug Utilization; Fixed-dose Combinations; Analgesics; Renal Failure; World Health Organization, CDSCO Forms; End Stage Renal Disease


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Inderpal Singh Grover
Articles by Deepa Latha C
Articles by Raja Vikram Prasad
Articles by Suvarchala Satyagama
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Grover IS, DLC, Prasad RV, Satyagama S. Analysis of drug use in patients of analgesic nephropathy. Natl J Physiol Pharm Pharmacol. 2022; 12(1): 84-87. doi:10.5455/njppp.2022.12.11416202126112021


Web Style

Grover IS, DLC, Prasad RV, Satyagama S. Analysis of drug use in patients of analgesic nephropathy. http://www.njppp.com/?mno=10971 [Access: January 01, 2022]. doi:10.5455/njppp.2022.12.11416202126112021


AMA (American Medical Association) Style

Grover IS, DLC, Prasad RV, Satyagama S. Analysis of drug use in patients of analgesic nephropathy. Natl J Physiol Pharm Pharmacol. 2022; 12(1): 84-87. doi:10.5455/njppp.2022.12.11416202126112021



Vancouver/ICMJE Style

Grover IS, DLC, Prasad RV, Satyagama S. Analysis of drug use in patients of analgesic nephropathy. Natl J Physiol Pharm Pharmacol. (2022), [cited January 01, 2022]; 12(1): 84-87. doi:10.5455/njppp.2022.12.11416202126112021



Harvard Style

Grover, I. S., , . D. L. C., Prasad, . R. V. & Satyagama, . S. (2022) Analysis of drug use in patients of analgesic nephropathy. Natl J Physiol Pharm Pharmacol, 12 (1), 84-87. doi:10.5455/njppp.2022.12.11416202126112021



Turabian Style

Grover, Inderpal Singh, Deepa Latha C, Raja Vikram Prasad, and Suvarchala Satyagama. 2022. Analysis of drug use in patients of analgesic nephropathy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (1), 84-87. doi:10.5455/njppp.2022.12.11416202126112021



Chicago Style

Grover, Inderpal Singh, Deepa Latha C, Raja Vikram Prasad, and Suvarchala Satyagama. "Analysis of drug use in patients of analgesic nephropathy." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 84-87. doi:10.5455/njppp.2022.12.11416202126112021



MLA (The Modern Language Association) Style

Grover, Inderpal Singh, Deepa Latha C, Raja Vikram Prasad, and Suvarchala Satyagama. "Analysis of drug use in patients of analgesic nephropathy." National Journal of Physiology, Pharmacy and Pharmacology 12.1 (2022), 84-87. Print. doi:10.5455/njppp.2022.12.11416202126112021



APA (American Psychological Association) Style

Grover, I. S., , . D. L. C., Prasad, . R. V. & Satyagama, . S. (2022) Analysis of drug use in patients of analgesic nephropathy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (1), 84-87. doi:10.5455/njppp.2022.12.11416202126112021